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Povezanost polimorfizmov v genih za glutation peroksidazo in glutation disulfid reduktazo s koncentracijo 8-hidroksi-deoksigvanozina v urinu = Correlation between glutathione peroxydase and glutathione-disulfide reductase gene polymorphisms and 8-hydroxydeoxyguanosine urine concentration : magistrski študijski program Laboratorijska biomedicina
Vukoja, Jure, farmacevt
Endogeni 8-hidroksi-deoksi gvanozin (8-OHdG) nastaja kot posledica reakcije hidroksilnega radikala z deoksigvanozinskimi ostanki, njegova prisotnost pa lahko povzroči transverzijske mutacije GC>TA, ...ki vodijo v polimorfizme ter hitrejše krajšanje telomer. Uporablja se tako kot diagnostični kot prognostični kazalnik stanj, ki so posledica oksidativnega stresa v telesu. Izloča se z urinom, kar omogoča neinvaziven odvzem in merjenje koncentracije pri posamezniku. Glutation-peroksidaze so družina encimov, ki organizem ščitijo pred oksidativnimi poškodbami preko redukcije vodikovega peroksida. Po drugi strani pa encimi glutation-reduktaze, čigar vloga je redukcija oksidirane oblike glutationa - GSSG nazaj v sulfhidrilno obliko - GSH, na ta način posredno delujejo kot obrambni element proti oksidativnemu stresu. Namen magistrskega dela je bil primerjati metodi RFLP in PCR v realnem času ter ugotoviti morebitno povezanost polimorfizmov rs1050450 G.
Type of material - master's thesis
; adult, serious
Publication and manufacture - Ljubljana : [J. Vukoja], 2021
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