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Načrtovanje in sinteza novih derivatov glukozamina za uporabo v katalitskih sistemih s prehodnimi kovinami = Design and synthesis of new glucosamine derivatives for the application in transition-metal catalytic systems : enoviti magistrski študijski program FarmacijaRode, DanajaKobaltovi katalizatorji se v zadnjih letih vedno bolj uporabljajo za tvorbo vezi ogljik-ogljik. Prednost kobalta pred ostalimi prehodnimi kovinami je predvsem njegova dostopnost, nizka toksičnost ter ... nizka cena. Zaradi naštetih razlogov spadajo katalitski sistemi, ki kot katalizator uporabljajo kobaltove komplekse, med bolj ekološke. Reakcije z njimi potekajo v dokaj milih pogojih, za potek reakcije pa potrebujemo še bazo in ligand, s katerim kobalt tvori kompleks predhodno, ali pa in-situ. Tekom izdelave magistrske naloge smo sintetizirali nove derivate glukozamina kot ligande za katalitske sisteme. V teh sistemih z uporabo Grignardovih reagentov in s pomočjo kobalta in ligandov stereoselektivno tvorimo nove vezi ogljik-ogljik. Sintetizirali smo 8 potencialnih ligandov, od katerih smo nato tri uporabili v izbranem katalitskem sistemu. Sintetizirane spojine smo testirali tudi na encimih acetilholinesteraza, butirilholinesteraza in monoaminooksidaza A in B. Zaviralno aktivnost sta izkazovali dve spojini, in sicer na encimu butirilholinesteraza. Nazadnje smo ligandom določili tudi sposobnost kelacije nekaterih prehodnih kovin. Komplekse s kobaltom (Co2+) je tvorilo šest spojin, z železom (Fe2+) pa ena. Spojine, sposobne kelacije prehodnih kovin, se lahko potencialno uporabijo kot zdravilne učinkovine, kot kelatorji, ali pa kot učinkovine, kjer je prehodna kovina del zdravilne učinkovine in igra pri klinični aplikaciji ključno vlogo. Anorganska farmacevtska kemija je v uporabi sicer še vedno na drugem mestu za organsko kemijo, a številne raziskave v zadnjem desetletju dokazujejo njen potencial na številnih področjih medicine in farmacije. Sintetizirane derivate glukozamina smo tako uporabili za tri različne namene: - kot ligande v katalitskih sistemih, kjer smo tvorili nove vezi ogljik-ogljik; - kot potencialne zaviralce encimov AChE, BChE, MAO-A in MAO-B; - kot kelatorje nekaterih prehodnih kovin.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [D. Rode], 2019Language - slovenianCOBISS.SI-ID - 4826225
Author
Rode, Danaja
Other authors
Frlan, Rok
Topics
Kobalt |
katalitski sistem |
sinteza spojin |
ligandi |
glukozamin |
kompleks |
butirilholinesteraza
Library/institution |
City | Acronym | For loan | Other holdings |
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Faculty of Pharmacy, Ljubljana | Ljubljana | FFALJ |
reading room 1 cop.
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Rode, Danaja | |
Frlan, Rok | 26512 |
Source: Personal bibliographies
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