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  • Evolving a peptide [Elektronski vir] : library platforms and diversification strategies
    Bozovičar, Krištof ; Bratkovič, Tomaž, farmacevt, 1978-
    Peptides are widely used in pharmaceutical industry as active pharmaceutical ingredients, versatile tools in drug discovery, and for drug delivery. They find themselves at the crossroads of small ... molecules and proteins, possessing favorable tissue penetration and the capability to engage into specific and high-affinity interactions with endogenous receptors. One of the commonly employed approaches in peptide discovery and design is to screen combinatorial libraries, comprising a myriad of peptide variants of either chemical or biological origin. In this review, we focus mainly on recombinant peptide libraries, discussing different platforms for their display or expression, and various diversification strategies for library design. We take a look at well-established technologies as well as new developments and future directions.
    Source: International journal of molecular sciences [Elektronski vir]. - ISSN 1422-0067 (Vol. 21, no. 1, 2020, str. 1-31)
    Type of material - e-article
    Publish date - 2020
    Language - english
    COBISS.SI-ID - 4866673

    Link(s):

    https://www.mdpi.com/1422-0067/21/1/215
    Repository of the University of Ljubljana – RUL
    DOI

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