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  • Unique structural features of interconverting monomeric and dimeric G-quadruplexes adopted by a sequence from the intron of the N-myc gene
    Trajkovski, Marko, 1984- ; Webba da Silva, Mateus ; Plavec, Janez
    A multidimensional heteronuclear NMR study has demonstrated that a guanine-rich DNA oligonucleotide originating from the N-myc gene folds into G-quadruplex structures in the presence of K+, NH4+, and ... Na+ ions. A monomericG-quadruplex formed in K+ ion containing solution exhibits three G-quartets and flexible propeller-type loops. The 3D structure with three single nucleotide loops represents a missing element in structures of parallelG-quadruplexes. The structural features together with the high temperature stability are suggestive of the specific biological role of G-quadruplex formation within the intron of the N-myc gene. An increase in K+ ion and oligonucleotide concentrations resulted in transformation of the monomeric G-quadruplex into a dimeric form. The dimeric G-quadruplex exhibits six stacked G-quartets, parallel strand orientations, and propeller-type loops. A link between the third and the fourth G-quartets consists of two adenine residues that are flipped out to facilitate consecutive stacking of six G-quartets
    Source: Journal of the American Chemical Society : JACS. - ISSN 0002-7863 (Vol. 134, iss. 9, 2012, str. 4132-4141)
    Type of material - article, component part
    Publish date - 2012
    Language - english
    COBISS.SI-ID - 4920602

    Link(s):

    http://pubs.acs.org/doi/abs/10.1021/ja208483v

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