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Preoblikovalni rastni faktorji-beta1 v dlesni in njeni tekočini pri parodontalni bolezni = Transforming growth factor beta1 in gingiva and crevicular fluid in periodontal disease
Artnik, Barbara ; Skalerič, Uroš, 1945-2023
The transforming growth factor beta1 (TGF-beta1) represents a family of protein growth factors involved in embryogenesis, wound healing, tumour progression, inflammation and regulation of immune ...processes. The aim of this study was to evaluate the concentration of TGF-beta1 in gingiva and. in crevicular fluid of patients with periodontal disease. Gingival tissue was obtained from nine patients in need of periodontal surgery. Gingival fluid wascollected with paper strips (periopaper, Harco, Irvine, MA, USA) from ten patients with different degrees of periodontal disease. The fluid volume was measured with a Petriotron device (Siemens, Germany). Supragingival plaque wasassessed with the plaque index (PI). The clinical status of periodontal tissue was evaluated with the gingival index (GI), measurement of probing depth (PD) and epithelial attachment loss (EAL). An ELISA kit (Predicta TGF-beta1, Genzyme, Diagnostic Co., Cambrige, MA, USA) was used to quantitate the amount of TGF-beta1, in supermatants of gingival homogenates and in fluid samples. Statistical analysis was performed with fisherćs transformation of the correlation oefficient and Studentćs t-test. TGF-beta1 was present in all gingival tissue and fluid samples studiedč its levels in the tissue ranged from 8.8 to 20.0 ngžml, and in the fluid from 49.5 to 868.6 ngžml. TGF-beta, was insignificantly elevated in tissue and fluid samples obtained from sites with greater plaque accumulation and advanced gingival inflammation. Significantly elevated TGF-beta1 levels were found in tissue (r=0.87, p < 0.005) and fluid samples (5 = 0.59, p < 0.05) taken from sites with deep pockets. Tissue TGF-beta1 levels were correlated with EAL (r = 0.87, p < 0.005), but the relationship between TGF-beta1 in gingival fluid and EAL was insignificant. The present study revealed increased levels of the transforminggrowth factor beta1 in gingival tissues and fluid from patients with advanced periodontal disease.(Abstract truncated)
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