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NMR-struktura G-kvadrupleksa iz genoma človeškega papilomskega virusa = NMR structure of a G-quadruplex from human papilloma virus genomeMarušič, MajaZ gvanini bogata zaporedja DNA lahko tvorijo G-kvadruplekse - helične strukture, v katerih so s Hoogstenovimi vodikovimi vezmi med seboj povezane štiri verige DNA. Osredotočili smo se na z gvanini ... bogato zaporedje iz genoma človeškega papilomskega virusa (HPV) tipa 52. Okužbe z nekaterimi tipi HPV lahko povzročijo predrakave in rakave spremembe, zato je zanimanje za razvoj specifičnega zdravila proti HPV veliko. Eden izmed pristopov bi lahko bil stabilizacija z gvanini bogatih zaporedij v regulatornih regijah genoma HPV, kar bi lahko vplivalo na podvajanje in prepisovanje genov ali celotnega genomaHPV. Cilj raziskave je bil določiti prostorsko strukturo visoke ločljivosti G-kvadrupleksa iz genoma HPV tipa 52. S pomočjo jedrske magnetne resonance smo ugotovili, da zaporedje iz genoma HPV tipa 52 v prisotnosti ionov K+ tvori G-kvadrupleks. Za nedvoumno določitev resonanc imino protonov smo posneli dušikove 1D 15N-1H HSQC spektre 15N označenih oligonukleotidov. S pomočjo 2D-spektrov 13C-1H JRHMBC smo določili nedvoumno asignacijo H8 protonov gvaninov. Asignacija neizmenljivih protonov je potekala s pomočjo 2D-spektrov DQF-COSY, NOESY in TOCSY. Ugotovili smo, da zaporedje iz genoma HPV tipa 52 tvori G-kvadrupleks s tremi vzporednimi in eno antiparalelno verigo, povezujejo pa jih propelerska, diagonalna in robna zanka, dolga dva, pet in tri nukleotide. Prostorska struktura z atomsko resolucijo 3+1 G-kvadrupleksa iz genoma HPV tipa 52 omogoča načrtovanje specifičnih ligandov,ki bi lahko vplivali na izražanje genov HPV 52.Source: 42. Krkine nagrade : znanost povezuje : zbornik povzetkov : 22. simpozij, Novo mesto, 19. oktober 2012 (Str. 67)Type of material - conference contributionPublish date - 2012Language - slovenian, englishCOBISS.SI-ID - 5110810
Author
Marušič, Maja
Other authors
Plavec, Janez
Topics
kemija |
genom človeškega papilomskega virusa |
genomi HPV |
načrtovanje ligandov |
načrtovanje ligandov
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Marušič, Maja | 34525 |
Plavec, Janez | 10082 |
Source: Personal bibliographies
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