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  • ▫$\beta$▫-cells operate collectively to help maintain glucose homeostasis
    Podobnik, Boris ...
    Residing in the islets of Langerhans in the pancreas, [beta]-cells contribute to glucose homeostasis by managing the body's insulin supply. Although it has been acknowledged that healthy [beta]-cells ... engage in heavy cell-to-cell communication to perform their homeostatic function, the exact role and effects of such communication remain partly understood. We offer a novel perspective on the subject in the form of (i) a dynamical network model that faithfully mimics fast calcium oscillations in response to above-threshold glucose stimulation and (ii) empirical data analysis that reveals a qualitative shift in the cross-correlation structure of measured signals below and above the threshold glucose concentration. Combined together, these results point to a glucose-induced transition in [beta]-cell activity thanks to increasing coordination through gap-junctional signaling and paracrine interactions. Our data and the model further suggest how the conservation of entire cell-cell conductance, observed in coupled but not uncoupled [beta]-cells, emerges as a collective phenomenon. An overall implication is that improving the ability to monitor [beta]-cell signaling should offer means to better understand the pathogenesis of diabetes mellitus.
    Source: Biophysical journal [Elektronski vir]. - ISSN 1542-0086 (Vol. 118, iss. 10, 19 May 2020, str. 2588-2595)
    Type of material - e-article
    Publish date - 2020
    Language - english
    COBISS.SI-ID - 512974648

    Link(s):

    https://www.cell.com/biophysj/fulltext/S0006-3495(20)30308-8#%20
    DOI

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