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Infantile hemangioendothelioma of the liver in a neonateCerar, Anton, 1945- ; Dolenc-Stražar, Zvezdana ; Bartenjev, D...The study documents the immunohistochemical features of a case of infantile hemangioendothelioma (IHE) of the liver, which was found incidentally at autopsy in a 44-day-old girl. A precardial apical ... systolic murmur and hepatomegaly were found on day 4 of life. The tumor was multifocal and histologically composed of vascular channels lined by endothelial cells that were positive for von Willebrand factor, CD31, vimentin, adn Ulex europaeus agglutinin 1, and that were invested in a continous basement membrane (BM) on the antiluminal border. The endothelial cells, especially in the region of intravascular buds, showed intracytoplasmic synthesis of BM components (laminin and collagen IV). Inderlying the endothelial cells were cells with cytoplasm that was positive for alpha-smoooth muscle actin and antimuscle actin and negative for desmin, and that were enveloped with BM. The immunophenotype, appearance, and location of these cells are characteristic of pericytes. We found neither signs of endocrine secretion nor hepatitis B virus in the tumor tissue. The appearance of this tumor in the neonatal period supports a fetal origin of IHE.Source: The American journal of surgical pathology. - ISSN 0147-5185 (Let. 20, št. 7, 1996, str. 871-876)Type of material - article, component partPublish date - 1996Language - englishCOBISS.SI-ID - 5157849
Author
Cerar, Anton, 1945- |
Dolenc-Stražar, Zvezdana |
Bartenjev, D...
Topics
Hemangioendothelioma |
Pathology |
Immunology |
Metabolism |
Liver neoplasms |
Pathology |
Immunology |
Metabolism |
Immunohistochemistry |
Laminin |
Metabolism |
Vimentin |
Metabolism |
Cell adhesion molecules |
Metabolism |
Basement membrane |
Pathology |
Metabolism |
Actins |
Metabolism |
Antigens, differentiation, myelomonocytic |
Metabolism |
Von willebrand factor |
Metabolism
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Database name | Field | Year |
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Cerar, Anton, 1945- | 05367 |
Dolenc-Stražar, Zvezdana | 06207 |
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