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Ca[sup]2+ as the prime trigger of aerobic glycolysis in astrocytes [Elektronski vir]Horvat, Anemari ...Astroglial aerobic glycolysis, a process during which d-glucose is converted to l-lactate, a brain fuel and signal, is regulated by the plasmalemmal receptors, including adrenergic receptors (ARs) ... and purinergic receptors (PRs), modulating intracellular Ca2+ and cAMP signals. However, the extent to which the two signals regulate astroglial aerobic glycolysis is poorly understood. By using agonists to stimulate intracellular [alpha]1-/[beta]-AR-mediated Ca2+/cAMP signals, [beta]-AR-mediated cAMP and P2R-mediated Ca2+ signals and genetically encoded fluorescence resonance energy transfer-based glucose and lactate nanosensors in combination with real-time microscopy, we show that intracellular Ca2+, but not cAMP, initiates a robust increase in the concentration of intracellular free d-glucose ([glc]i) and l-lactate ([lac]i), both depending on extracellular d-glucose, suggesting Ca2+-triggered glucose uptake and aerobic glycolysis in astrocytes. When the glycogen shunt, a process of glycogen remodelling, was inhibited, the [alpha]1-/[beta]-AR-mediated increases in [glc]i and [lac]i were reduced by %65 % and %30 %, respectively, indicating that at least %30 % of the utilization of d-glucose is linked to glycogen remodelling and aerobic glycolysis. Additional activation of [beta]-AR/cAMP signals aided to [alpha]1-/[beta]-AR-triggered [lac]i increase, whereas the [glc]i increase was unaltered. Taken together, an increase in intracellular Ca2+ is the prime mechanism of augmented aerobic glycolysis in astrocytes, while cAMP has only a moderate role. The results provide novel information on the signals regulating brain metabolism and open new avenues to explore whether astroglial Ca2+ signals are dysregulated and contribute to neuropathologies with impaired brain metabolism.Source: Cell calcium. - ISSN 1532-1991 (Vol. 95, May 2021, str. 1-11)Type of material - e-articlePublish date - 2021Language - englishCOBISS.SI-ID - 52558339
Author
Horvat, Anemari |
Muhič, Marko, 1986- |
Smolič, Tina, biologinja |
Begić, Ena |
Zorec, Robert, 1958- |
Kreft, Marko |
Vardjan, Nina
Topics
astrocytes |
aerobic glycolysis |
d-glucose |
astrociti |
aerobna glikoliza |
d-glukoza
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Horvat, Anemari | 36369 |
Muhič, Marko, 1986- | 34356 |
Smolič, Tina, biologinja | 39164 |
Begić, Ena | 54657 |
Zorec, Robert, 1958- | 03702 |
Kreft, Marko | 15666 |
Vardjan, Nina | 20214 |
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