ALL libraries (COBIB.SI union bibliographic/catalogue database)
-
The use of model simplifications and scale-independent parameters for building a design space on the film coating process = Uporaba modelskih poenostavitev in od ravni neodvisnih spremenljivk pri postavitvi eksperimentalnega prostora za proces filmskega oblaganja tablet : doktorska disertacijaDebevec, VeronikaThe objective of the doctoral study was to develop scale-independent design space for the film coating process. We coated hygroscopic tablet cores with a moisture protective polyvinyl alcohol coating ... in order to protect the hydrolysable model drug substance from environmental moisture. Since we could not discover a universal approach for design space development, based on an overview of the current literature, we have outlined throughout this work, in our opinion, the most optimal approach: (1) We used scale-independent coating process parameters (product temperature, polymer dispersion droplet size and process relative humidity) as input variables for a face-centered central composite design. (2) We combined empirical as well as mechanistic modeling, and utilized model simplifications to quantitatively link the scale-independent parameters to scale-dependent ones (inlet air temperature, inlet air flow rate, inlet air humidity, coating dispersion spray rate, atomizing air pressure) in order to perform experiments. For elucidating the mechanisms, through which scale-independent parameters influence the product quality attributes, we selected the following responses: (1) The permeability of the film coating in order to assess film formation and consequently coating functionality in terms of moisture protection. (2) Water activity of film coated tablets (FCT) at the end of the spraying phase. Further, we correlated both responses with long-term stability results of FCT. Based on the obtained models and implementation of the proper constraints on responses, we determined a complete sequence of design spaces, connecting scale- independent spaces with scale-dependent ones. The main findings are the following: (1) Model simplifications and hybrid modeling can adequately describe the coating process and could be used for building a design space, which is independent of manufacturing scale.(2) With scale-independent design space in the coating process, it is possible to efficiently predict, control, and optimize the long-term stability of a moisture sensitive product. (3) During the film coating process, humidity conditions play the most important role in achieving product quality. However, the moisture protective coating itself has a negative influence on product stability for packaging configurations with a desiccant, due to keeping the moisture inside the FCT and preventing the desiccant from effectively drying out the FCT.Type of material - dissertation ; adult, seriousPublication and manufacture - Ljubljana : [V. Debevec], 2021Language - englishCOBISS.SI-ID - 57124611
Link(s):
Repository of the University of Ljubljana – RUL
Digitalna knjižnica Slovenije - dLib.siDostop z namenskih računalnikov v prostorih NUK
Author
Debevec, Veronika
Other authors
Srčič, Stanko |
Horvat, Matej, 1979-
Topics
Farmacevtska tehnologija |
tablete |
filmsko oblaganje |
vodna aktivnost tablet |
stabilnost izdelkov |
obložene tablete
Library/institution |
City | Acronym | For loan | Other holdings |
---|---|---|---|---|
Central Technological Library of the University of Ljubljana | Ljubljana | CTK |
outside loan 1 cop.
|
|
Faculty of Pharmacy, Ljubljana | Ljubljana | FFALJ |
reading room 1 cop.
|
|
National and University Library, Ljubljana | Ljubljana | NUK |
reading room 1 cop.
|
not for loan 1 cop.
|
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Debevec, Veronika | 35859 |
Srčič, Stanko | 09031 |
Horvat, Matej, 1979- | 22306 |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location: