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Biological factors of the tumour response to electrochemotherapy : review of the evidence and a research roadmapSerša, Gregor ...The beneficial effects of electrochemotherapy (ECT) for superficial tumours and, more recently, deepseated malignancies in terms of local control and quality of life are widely accepted. However, the ... variability in responses across histotypes needs to be explored. Currently, patient selection for ECT is based on clinical factors (tumour size, histotype, and exposure to previous oncological treatments), whereas there are no biomarkers to predict the response to treatment. In this field, two major areas of investigation can be identified, i.e., tumour cell characteristics and the tumour microenvironment (vasculature, extracellular matrix, and immune infiltrate). For each of these areas, we describe the current knowledge and discuss how to foster further investigation. This review aims to provide a summary of the currently used guiding clinical factors and delineates a research roadmap for future studies to identify putative biomarkers of response to ECT. These biomarkers may allow researchers to improve ECT practice by customising treatment parameters, manipulating the tumour and its microenvironment, and exploring novel therapeutic combinations.Source: European journal of surgical oncology. - ISSN 0748-7983 (Vol. 47, iss. 8, 2021, str. 1836-1846)Type of material - article, component partPublish date - 2021Language - englishCOBISS.SI-ID - 57155587
Author
Serša, Gregor |
Uršič Valentinuzzi, Katja, 1990- |
Čemažar, Maja |
Heller, Richard |
Omerzel, Maša, mag. farm. |
Campana, Luca Giovanni, dr. med.
Topics
biološki dejavniki |
biološki označevalci |
elektrokemoterapija |
bleomycin |
cisplatin |
biological factors |
biomarkers |
electrochemotherapy |
bleomycin |
cisplatin
Author | Serša, Gregor ... |
Title | Biological factors of the tumour response to electrochemotherapy : review of the evidence and a research roadmap |
Publication date | 2021-03-11 |
COBISS.SI-ID | 57155587 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Klinično farmakološki pristop k optimizaciji terapevtske koncentracije bleomicina zazdravljenje z elektrokemoterapijo | J3-9269-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Razvoj in ovrednotenje novih terapij za zdravljenje malignih tumorjev | P3-0003-2015 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
|
Elektrokemoterapija kot in situ vakcinacija | Z3-2651-2020 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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https://dirros.openscience.si/IzpisGradiva.php?id=15582 |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Serša, Gregor | 08800 |
Uršič Valentinuzzi, Katja, 1990- | 38223 |
Čemažar, Maja | 14575 |
Heller, Richard | |
Omerzel, Maša, mag. farm. | 34373 |
Campana, Luca Giovanni, dr. med. |
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