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Trends and timing of risk-reducing mastectomy uptake in unaffected BRCA1 and BRCA2 carriers in SloveniaLožar, Taja ...Objectives. Risk-reducing mastectomy (RRM) is one of key prevention strategies in female carriers of germline BRCA pathogenic/likely pathogenic variants (PV/LPV). We retrospectively investigated the ... rate, timing and longitudinal trends of bilateral RRM uptake and the incidence and types of cancers among unaffected BRCA carriers who underwent genetic counseling at the Institute of Oncology Ljubljana in Slovenia. Materials and Methods. Female BRCA carriers without personal history of cancer were included in the study. Clinical data on PV/LPV type, date of RRM, type of reconstructive procedure, occult carcinoma and histopathology results was collected and analyzed. Results. Of the 346 unaffected BRCA carriers (median age 43 years, 70% BRCA1, 30% BRCA2, median follow-up 46 months) who underwent genetic testing between October 1999 and December 2019, 25.1% had a RRM (range 35-50 years, median age at surgery 38 years). A significant difference in time to prophylactic surgery between women undergoing RRM only vs. women undergoing RRM combined with risk-reducing salpingo-oophorectomy was observed (22.6 vs 8.7 months, p=0.0009). We observed an upward trend in the annual uptake in line with the previously observed Angelina Jolie effect. In 5.7% of cases, occult breast cancer was detected. No women developed breast cancer after RRM. Women who did not opt for surgical prevention developed BRCA1/2-related cancers (9.3%). Conclusion. The uptake of RRM among unaffected BRCA carriers is 25.1% and is similar to our neighboring countries. No women developed breast cancer after RRM while women who did not opt for surgical prevention developed BRCA1/2 related cancers in 9.3% of cases. The reported data may provide meaningful aid for carriers when deciding on an optimal prevention strategy.Source: European journal of surgical oncology. - ISSN 0748-7983 (Vol. 47, no. 8, Aug. 2021, str. 1900-1906)Type of material - article, component partPublish date - 2021Language - englishCOBISS.SI-ID - 57272579
Author
Ložar, Taja |
Žgajnar, Janez, 1963- |
Perhavec, Andraž |
Blatnik, Ana, 9.8.1980- |
Novaković, Srdjan |
Krajc, Mateja
Topics
preventivna mastektomija |
rak dojke |
BRCA |
gen BRCA |
risk-reducing mastectomy |
breast cancer |
BRCA
Author | Ložar, Taja ... |
Title | Trends and timing of risk-reducing mastectomy uptake in unaffected BRCA1 and BRCA2 carriers in Slovenia |
Publication date | 2021-03-26 |
COBISS.SI-ID | 57272579 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
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Družine s povišano ali visoko ogroženostjo za raka: svetovanje, odkrivanje mutacij in preprečevanje raka | P3-0352-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Files that belong to the publication
Link |
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https://dirros.openscience.si/IzpisGradiva.php?id=15566 |
source: European journal of surgical oncology. - ISSN 0748-7983 (Vol. 47, no. 8, Aug. 2021, str. 1900-1906)
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Ložar, Taja | |
Žgajnar, Janez, 1963- | 12767 |
Perhavec, Andraž | 26530 |
Blatnik, Ana, 9.8.1980- | 32428 |
Novaković, Srdjan | 08007 |
Krajc, Mateja | 27594 |
Source: Personal bibliographies
and: SICRIS
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