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  • Functional hierarchy underlies preferential connectivity disturbances in schizophrenia [Elektronski vir]
    Yang, Genevieve J. ...
    Schizophrenia may involve an elevated excitation/inhibition (E/I) ratio in cortical microcircuits. It remains unknown how this regulatory disturbance maps onto neuroimaging findings. To address this ... issue, we implemented E/I perturbations within a neural model of large-scale functional connectivity, which predicted hyperconnectivity following E/I elevation. To test predictions, we examined resting-state functional MRI in 161 schizophrenia patients and 164 healthy subjects. As predicted, patients exhibited elevated functional connectivity that correlated with symptom levels, and was most prominent in association cortices, such as the fronto-parietal control network. This pattern was absent in patients with bipolar disorder (n = 73). To account for the pattern observed in schizophrenia, we integrated neurobiologically plausible, hierarchical differences in association vs. sensory recurrent neuronal dynamics into our model. This in silico architecture revealed preferential vulnerability of association networks to E/I imbalance, which we verified empirically. Reported effects implicate widespread microcircuit E/I imbalance as a parsimonious mechanism for emergent inhomogeneous dysconnectivity in schizophrenia.
    Source: Proceedings of the National Academy of Sciences of the United States of America [Elektronski vir]. - ISSN 1091-6490 (Vol. 113, no. 2, 2016, 10 str.)
    Type of material - e-article ; adult, serious
    Publish date - 2016
    Language - english
    COBISS.SI-ID - 59259490

    Link(s):

    http://www.pnas.org/content/early/2015/12/22/1508436113
    DOI

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