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Seroprevalence of severe acute respiratory syndrome coronavirus 2 in Slovenia : results of two rounds of a nationwide population study on a probability-based sample, challenges and lessons learnedPoljak, Mario, 1965- ...Objectives: Seroprevalence surveys provide crucial information on cumulative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure. This Slovenian nationwide population study is the ... first longitudinal 6-month serosurvey using probability-based samples across all age categories. Methods: Each participant supplied two blood samples: 1316 samples in April 2020 (first round) and 1211 in October/November 2020 (second round). The first-round sera were tested using Euroimmun Anti-SARS-CoV-2 ELISA IgG (ELISA) and, because of uncertain estimates, were retested using Elecsys Anti-SARS-CoV-2 (Elecsys-N) and Elecsys Anti-SARS-CoV-2 S (Elecsys-S). The second-round sera were concomitantly tested using Elecsys-N/Elecsys-S. Results: The populations of both rounds matched the overall population (n = 3000), with minor settlement type and age differences. The first-round seroprevalence corrected for the ELISA manufacturer's specificity was 2.78% (95% highest density interval [HDI] 1.81%-3.80%), corrected using pooled ELISA specificity calculated from published data 0.93% (95% CI 0.00%-2.65%), and based on Elecsys-N/Elecsys-S results 0.87% (95% HDI 0.40%-1.38%). The second-round unadjusted lower limit of seroprevalence on 11 November 2020 was 4.06% (95% HDI 2.97%-5.16%) and on 3 October 2020, unadjusted upper limit was 4.29% (95% HDI 3.18%-5.47%). Conclusions: SARS-CoV-2 seroprevalence in Slovenia increased four-fold from late April to October/November 2020, mainly due to a devastating second wave. Significant logistic/methodological challenges accompanied both rounds. The main lessons learned were a need for caution when relying on manufacturer-generated assay evaluation data, the importance of multiple manufacturer-independent assay performance assessments, the need for concomitant use of highly-specific serological assays targeting different SARS-CoV-2 proteins in serosurveys conducted in low-prevalence settings or during epidemic exponential growth and the usefulness of a Bayesian approach for overcoming complex methodological challenges.Source: Clinical microbiology and infection : the official publication of the European society of clinical microbiology and infectious dieseases. - ISSN 1198-743X (Vol. 27, iss. 7, Jul. 2021, str. 1039.e1-1039.e7)Type of material - article, component part ; adult, seriousPublish date - 2021Language - englishCOBISS.SI-ID - 62248195
Author
Poljak, Mario, 1965- |
Oštrbenk Valenčak, Anja |
Štrumbelj, Erik |
Maver Vodičar, Polona |
Vehovar, Vasja |
Resman Rus, Katarina |
Korva, Miša |
Knap, Nataša, 1978- |
Seme, Katja, 1966- |
Petrovec, Miroslav |
Zupan, Blaž, računalništvo |
Demšar, Janez, računalništvo |
Kurdija, Slavko |
Avšič-Županc, Tatjana
Topics
coronavirus disease 2019 |
probability-based sample |
severe acute respiratory syndrome |
koronavirusna bolezen 2019 |
vzorec na podlagi verjetnosti |
hud akutni respiratorni sindrom
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Poljak, Mario, 1965- | 11622 |
Oštrbenk Valenčak, Anja | 35359 |
Štrumbelj, Erik | 29486 |
Maver Vodičar, Polona | 36669 |
Vehovar, Vasja | 10155 |
Resman Rus, Katarina | 35044 |
Korva, Miša | 30696 |
Knap, Nataša, 1978- | 28601 |
Seme, Katja, 1966- | 14504 |
Petrovec, Miroslav | 15902 |
Zupan, Blaž, računalništvo | 12536 |
Demšar, Janez, računalništvo | 16324 |
Kurdija, Slavko | 12527 |
Avšič-Županc, Tatjana | 10331 |
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