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  • Altered global signal topography in schizophrenia [Elektronski vir]
    Yang, Genevieve J. ...
    Schizophrenia (SCZ) is a disabling neuropsychiatric disease associated with disruptions across distributed neural systems. Resting-state functional magnetic resonance imaging has identified extensive ... abnormalities in the blood-oxygen leveldependent signal in SCZ patients, including alterations in the average signal over the brain - i.e. the "global" signal (GS). It remains unknown, however, if these "global" alterations occur pervasively or follow a spatially preferential pattern. This study presents the first network-by-network quantification of GS topography in healthy subjects and SCZ patients. We observed a nonuniform GS contribution in healthy comparison subjects, whereby sensory areas exhibited the largest GS component. In SCZ patients, we identified preferential GS representation increases across association regions, while sensory regions showed preferential reductions. GS representation in sensory versus association cortices was strongly anticorrelated in healthy subjects. This anti-correlated relationship was markedly reduced in SCZ. Such shifts in GS topography may underlie profound alterations in neural information flow in SCZ, informing development of pharmacotherapies.
    Source: Cerebral cortex [Elektronski vir]. - ISSN 1460-2199 (Vol. 27, iss. 11, 2017, str. 5156-5169)
    Type of material - e-article ; adult, serious
    Publish date - 2017
    Language - english
    COBISS.SI-ID - 66380898

    Link(s):

    https://academic.oup.com/cercor/article/27/11/5156/3056477
    DOI

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