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  • BMI in relation to sperm count : an updated systematic review and collaborativemeta-analysis
    Sermondade, Nathalie ...
    BACKGROUNDThe global obesity epidemic has paralleled a decrease in semen quality. Yet, the association between obesity and sperm parameters remains controversial. The purpose of this report was to ... update the evidence on the association between BMI and sperm count through a systematic review with meta-analysis.METHODSA systematic review of available literature (with no language restriction) was performed to investigate the impact of BMI on sperm count. Relevant studies published until June 2012 were identified from a Pubmed and EMBASE search. We also included unpublished data (n = 717 men) obtained from the Infertility Center of Bondy, France. Abstracts of relevant articles were examined and studies that could be included in this review were retrieved. Authors of relevant studies for the meta-analysis were contacted byemail and asked to provide standardized data.RESULTSA total of 21 studies were included in the meta-analysis, resulting in a sample of 13 077 men from the general population and attending fertility clinics. Data were stratified according to the total sperm count as normozoospermia, oligozoospermia and azoospermia. Standardized weighted mean differences in sperm concentration didnot differ significantly across BMI categories. There was a J-shaped relationship between BMI categories and risk of oligozoospermia or azoospermia. Compared with men of normal weight, the odds ratio (95% confidence interval) for oligozoospermia or azoospermia was 1.15 (0.93-1.43) for underweight, 1.11 (1.01-1.21) for overweight, 1.28 (1.06-1.55) for obese and 2.04 (1.59-2.62) for morbidly obese men.CONCLUSIONSOverweight and obesity were associated with an increased prevalence of azoospermia or oligozoospermia. The main limitation of this report is that studied populations varied, with men recruited from both the general population and infertile couples. Whether weight normalization could improve sperm parametersshould be evaluated further.
    Source: Emerging infectious diseases. - ISSN 1080-6040 (Vol. 19, iss. 3, maj/jun. 2013, str. 221-231)
    Type of material - article, component part ; adult, serious
    Publish date - 2013
    Language - english
    COBISS.SI-ID - 671660

    Link(s):

    http://humupd.oxfordjournals.org/content/early/2012/12/12/humupd.dms050.full.pdf+html
    DOI

source: Emerging infectious diseases. - ISSN 1080-6040 (Vol. 19, iss. 3, maj/jun. 2013, str. 221-231)
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