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  • Synthesis and evaluation of AKR1C inhibitory properties of A-ring halogenated oestrone derivatives
    Sinreih, Maša ...
    Facile syntheses of 3-O-carbamoyl, -sulfamoyl, or -pivaloyl derivatives of 13[alpha]-oestrone and its 17-deoxy counterpart have been carried out. Microwave-induced, Ni-catalysed Suzuki-Miyaura ... couplings of the newly synthesised phenol esters with phenylboronic acid afforded 3-deoxy-3-phenyl-13a-oestrone derivatives. The carbamate and pivalate esters proved to be suitable for regioselective arylations. 2-(4- Substituted) phenyl derivatives were synthesised via Pd-catalysed, microwave-assisted C-H activation reactions. An efficient, one-pot, tandem methodology was elaborated for the introduction of the carbamoyl or pivaloyl group followed by regioselective C-2-arylation and subsequent removal of the directing group. The antiproliferative properties of the novel 13a-oestrone derivatives were evaluated in vitro on five human adherent cancer cell lines of gynaecological origin. 3-Sulfamate derivatives displayed substantial cell growth inhibitory potential against certain cell lines. The newly identified antiproliferative compounds having hormonally inactive core might be promising candidates for the design of more active anticancer agents.
    Source: Journal of enzyme inhibition and medicinal chemistry. - ISSN 1475-6366 (Vol. 36, no. 1, 2021, str. 1500-1508)
    Type of material - article, component part
    Publish date - 2021
    Language - english
    COBISS.SI-ID - 67617027

    Link(s):

    Repository of the University of Ljubljana – RUL
    DOI

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