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Načrtovanje, sinteza in vrednotenje nitro derivatov 5-stirilnikotinonitrila kot zaviralcev monoamin oksidaze = Design, synthesis and evaluation of nitro derivatives of 5-styrylnicotinonitrile as monoamine oxidase inhibitors : Uniform Master's Study Progamme PharmacyKovše, Monika, farmacevtkaMonoamin oksidaza (MAO) je flavoencim, vezan na zunanjo mitohondrijsko membrano, ki katalizira reakcijo oksidativne deaminacije aminov. V telesu uravnava homeostazo in prenos signalov pomembnih ... monoaminskih nevrotransmitorjev, kot so serotonin, dopamin in noradrenalin. Ločimo dva izoencima, monoamin oksidazo A (MAO-A) in monoamin oksidazo B (MAO-B), ki se med sabo razlikujeta po selektivnosti za substrat, občutljivosti na zaviralce in porazdelitvi po tkivih. Zvečano aktivnost MAO in posledično znižane koncentracije monoaminskih nevrotransmitorjev povezujejo s številnimi nevrološkimi motnjami, hkrati pa pri reakciji oksidativne deaminacije nastajajo nevrotoksični produkti, ki prispevajo k oksidativnim poškodbam. Zaviralci MAO se zato že desetletja uporabljajo v terapiji številnih bolezni, kot so depresija, Parkinsonova bolezen in Alzheimerjeva bolezen. Prvi zaviralci MAO so bili neselektivni in ireverzibilni, danes pa razvoj stremi k selektivnim in reverzibilnim zaviralcev, saj ti povzročajo manj neželenih učinkov. Laboratorijsko delo je obsegalo sintezo in vrednotenje nitro derivatov 5-stirilnikotinonitrila. Spojine smo načrtovali na podlagi predhodnega raziskovanja potencialnih zaviralcev MAO na Katedri za farmacevtsko kemijo Fakultete za farmacijo Univerze v Ljubljani in na podlagi strukture znanega reverzibilnega zaviralca MAO-B safinamida. Zaviralno aktivnost spojin smo ovrednotili z biološkimi testiranji na humanih encimih MAO-A in MAO-B. Od skupno 16 testiranih spojin smo srednjo zaviralno aktivnost (IC50) v nanomolarnem območju določili osmim spojinam v primeru izoencima MAO-B in eni spojini v primeru izoencima MAO-A. Najboljše zaviralne sposobnosti sta izkazovali spojini (E)-2-kloro-5-(4-metoksi-2-nitrostiril)nikotinonitril (IC50 = 42.2 % 4.9 nM) in etil (E)-2-(4-(2-(5-cianopiridin-3-il)vinil)-3-nitrofenoksi)acetat (IC50 = 42.3 % 3.4 nM) na MAO-B izoencimu. Te vrednosti presegajo zaviralne sposobnosti safinamida (IC50 = 98 nM) in predstavljajo dobro usmeritev za nadaljnje raziskovanje zaviralcev MAO.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [M. Kovše], 2021Language - slovenianCOBISS.SI-ID - 68239107
Author
Kovše, Monika, farmacevtka
Other authors
Frlan, Rok
Topics
Farmacevtska kemija |
Nevrodegenerativne bolezni |
monoamin oksidaza |
MAO |
zaviralci |
nevrodegenerativne bolezni |
Parkinsonova bolezen |
sinteza spojin
Library/institution |
City | Acronym | For loan | Other holdings |
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Faculty of Pharmacy, Ljubljana | Ljubljana | FFALJ |
reading room 1 cop.
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Kovše, Monika, farmacevtka | |
Frlan, Rok | 26512 |
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