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  • Targeted cancer therapy using compounds activated by light [Elektronski vir]
    Dunkel, Petra ; Ilaš, Janez
    Cancer chemotherapy is affected by a modest selectivity and toxic side effects of pharmacological interventions. Among novel approaches to overcome this limitation and to bring to therapy more potent ... and selective agents is the use of light for selective activation of anticancer compounds. In this review, we focus on the anticancer applications of two light-activated approaches still in the experimental phase: photoremovable protecting groups (''photocages'') and photoswitches. We describe the structural considerations behind the development of novel compounds and the plethora of assays used to confirm whether the photochemical and pharmacological properties are meeting the stringent criteria for an efficient in vivo light-dependent activation. Despite its immense potential, light activation brings many challenges, and the complexity of the task is very demanding. Currently, we are still deeply in the phase of pharmacological tools, but the vivid research and rapid development bring the light of hope for potential clinical use.
    Source: Cancers [Elektronski vir]. - ISSN 2072-6694 (Vol. 13, iss. 13, 2021, str. 1-49)
    Type of material - e-article
    Publish date - 2021
    Language - english
    COBISS.SI-ID - 69036803

    Link(s):

    https://www.mdpi.com/2072-6694/13/13/3237
    Repository of the University of Ljubljana – RUL
    DOI

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