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Stability-indicating analytical approach for stability evaluation of lactoferrin [Elektronski vir]Osel, Nika, farmacevtka ...Lactoferrin is a multifunctional iron-binding glycoprotein in milk. Due to its potential for the treatment of various diseases, interest in products containing lactoferrin is increasing. However, as ... a protein, it is prone to degradation, which critically affects the quality of products. Therefore, the main purpose of our work was to develop a stability-indicating analytical approach for stability evaluation of lactoferrin. We were focused on two complementary methods: reversed-phase and size-exclusion chromatography. The stability-indicating nature of the selected methods was confirmed. They were successfully validated by following the ICH guidelines and applied to preliminary lactoferrin stability studies. Up to three degradation products, as well as aggregates and fragments of lactoferrin, were detected in various samples using complementary reversed-phase and size-exclusion chromatographic methods. The analytical approach was additionally extended with three spectroscopic techniques (absorbance, intrinsic fluorescence, and bicinchoninic acid method), which may provide valuable complementary information in some cases. The presented analytical approach allows the stability evaluation of lactoferrin in various samples, including the ability to detect differences in its degradation mechanisms. Furthermore, it has the potential to be used for the quality control of products containing lactoferrin.Source: Pharmaceutics [Elektronski vir]. - ISSN 1999-4923 (Vol. 13, iss. 7, 2021, str. 1-24)Type of material - e-articlePublish date - 2021Language - englishCOBISS.SI-ID - 70061059
Author
Osel, Nika, farmacevtka |
Planinšek Parfant, Timeja |
Kristl, Albin |
Roškar, Robert, 1975-
Topics
Spektroskopska analiza |
lactoferrin |
stability |
HPLC-UV |
spectroscopic methods |
stability-indicating approach |
proteins |
quality control |
proteini |
stabilnost |
laktoferin |
nadzor kakovosti
Author | Osel, Nika, farmacevtka ... |
Title | Stability-indicating analytical approach for stability evaluation of lactoferrin [Elektronski vir] |
Publication date | 2021-07-11 |
COBISS.SI-ID | 70061059 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
---|---|---|---|
Farmacevtska tehnologija: od dostavnih sistemov učinkovin do terapijskih izidov zdravil pri otrocih in starostnikih | P1-0189-2018 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
Files that belong to the publication
Link |
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https://www.mdpi.com/1999-4923/13/7/1065 |
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=135599 |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Osel, Nika, farmacevtka | 53673 |
Planinšek Parfant, Timeja | 52446 |
Kristl, Albin | 11122 |
Roškar, Robert, 1975- | 23549 |
Source: Personal bibliographies
and: SICRIS
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