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13.
Zdravljenje bolnikov, okuženih s HIV, s sakvinavirjem in dvema zaviralcema reverzne transkriptaze = Treatment of patients infected with HIV with saquinavir and two reverse transcriptase inhibitors
Tomažič, Janez, 1954- ...
In a prospective study, clinical, virological and immunological effects of a three drug combination therapy (saquinavir + two reverse transcriptase inhibitors) was assesed over a period of 32 weeks ...in antiretroviral-treated HIV infected patients (n = 8) and in antiretroviral-naive HIV infected patients (n = 5). In a treated group, the decrease of the median plasma HIV-1 RNA level after 3 and 8 months of treatment was 0.53 log and 0.69 log. The mean increase in CD4+ count after 3 and 8 months was 31 and 29 cells/micro l. Disease progression occurred in two patients, one patient stopped saquinavir due to diarrhea. In the untreated group the decrease of the median plasma HIV-1 RNA level after 3 and 6 months was 1.3 log and 1.98 log. The mean increase in CD4+ count after 3 and 6 months was 72 and 103 cells/micro. There was no clinical deterioration in the follow up period in this group. In our pilot study, a combination of saquinavir with two nucleoside analogs reduced plasma HIV-1 RNA levels and increased CD4+ cell counts. It seems that adding saquinavir was more effective in patients with no previous antiretroviral treatment. In general, saquinavir was well tolerated.
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