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Prognostična vrednost katepsina D in PS2 pri operabilnem raku dojk = Prognostic value of cathepsin D and PS2 in operable breast cancer
Žgajnar, Janez, 1963- ; Lindtner, Jurij
Bacground. Our assessment of prognosis in operable breast cancer patients and the choice of an appropriate therapy is based on prognostic factors. Promisingprognostic factors include cathepsin D, a ...lysosomal protease and PS2,a protein of yet unknown function. The aim of this study was to determine the prognostic significance of Cathepsin D and PS2. Methods. 153 operable breast cancer patients treated at the Institute of Oncology in Ljubljana were included in our study. Levels of cathepsin D and PS2 were immunoradiometrically determined in frozen tumour cytosols. The median follow-up period was 33 months. Univariate statistical analysis (Log Rank test) was performed to evaluate the survival. Results. out of 153 patients included in the study 43 patients (28%) relapsed and 24 patients (16%) died. The overall survival of patients with cathepsin D levels<-50 pmol/mg prot. wassignificantly better (p = 0,03) than that of the patients with higher values. The difference in disease-free survival was not statistically significant (p = 0,09). The overall survival of patients with PS2 levels<-2,2 ng/mg prot was significantly better than that of the patients with PS2 levels<-2,2 ng/mg prot. (p = 0,02). The difference in disease-free survival was not statistically significant (p = 0,48). The overall survival of patientswith PS2 levels<-2,2 (p = 0,02). Conclusions. Our univariate analysis has confirmed the prognostic value of cathepsin D and PS2 for overal survival but not for disease-free survival. Furthermore we have found that PS2 is particularly useful in the axillary lymphnode positive subgroup for the evaluation of overall survival.
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