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Combination of pembrolizumab with electrochemotherapy in cutaneous metastases from melanoma [Elektronski vir] : a comparative retrospective study from the InspECT and Slovenian Cancer RegistryCampana, Luca Giovanni, dr. med. ...Electrochemotherapy (ECT) is an effective locoregional therapy for cutaneous melanoma metastases and has been safely combined with immune checkpoint inhibitors in preliminary experiences. Since ECT ... is known to induce immunogenic cell death, its combination with immune checkpoint inhibitors might be beneficial. In this study, we aimed to investigate the effectiveness of ECT on cutaneous melanoma metastases in combination with pembrolizumab. We undertook a retrospective matched cohort analysis of stage IIIC%IV melanoma patients, included in the International Network for sharing practices of ECT (InspECT) and the Slovenian Cancer Registry. We compared the outcome of patients who received the following treatments: (a) pembrolizumab alone, (b) pembrolizumab plus ECT, and (c) ECT. The groups were matched for age, sex, performance status, and size of skin metastases. The local objective response rate (ORR) was higher in the pembrolizumab-ECT group than in the pembrolizumab group (78% and 39%, p < 0.001). The 1 year local progression-free survival (LPFS) rates were 86% and 51% (p < 0.001), and the 1 year systemic PFS rates were 64% and 39%, respectively (p = 0.034). The 1 year overall survival (OS) rates were 88% and 64%, respectively (p = 0.006). Our results suggest that skin-directed therapy with ECT improves superficial tumor control in melanoma patients treated with pembrolizumab. Interestingly, we observed longer PFS and OS in the pembrolizumab-ECT group than in the pembrolizumab group. These findings warrant prospective confirmation.Source: Cancers [Elektronski vir]. - ISSN 2072-6694 (Vol. 13, no. 17, 2021, str. 4289-1-4289-13)Type of material - e-articlePublish date - 2021Language - englishCOBISS.SI-ID - 74755075
Author
Campana, Luca Giovanni, dr. med. |
Perić, Barbara, 1976- |
Mascherini, Matteo |
Spina, Romina |
Kunte, Christian |
Kis, Erika |
Rozsa, Petra |
Quaglino, Pietro |
Čemažar, Maja |
Omerzel, Maša, mag. farm. |
Serša, Gregor
Topics
elektrokemoterapija |
metastatski melanom |
kožne metastaze |
electrochemotherapy |
metastatic melanoma |
skin metastases
Author | Campana, Luca Giovanni, dr. med. ... |
Title | Combination of pembrolizumab with electrochemotherapy in cutaneous metastases from melanoma [Elektronski vir] : a comparative retrospective study from the InspECT and Slovenian Cancer Registry |
Publication date | 2021-08-25 |
COBISS.SI-ID | 74755075 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
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Razvoj in ovrednotenje novih terapij za zdravljenje malignih tumorjev | P3-0003-2015 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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https://www.mdpi.com/2072-6694/13/17/4289 |
https://dirros.openscience.si/IzpisGradiva.php?id=15616 |
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APC – Article Processing Charge | 1893.60 € |
1893.60 € : Onkološki inštitut Ljubljana |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Campana, Luca Giovanni, dr. med. | |
Perić, Barbara, 1976- | 24299 |
Mascherini, Matteo | |
Spina, Romina | |
Kunte, Christian | |
Kis, Erika | |
Rozsa, Petra | |
Quaglino, Pietro | |
Čemažar, Maja | 14575 |
Omerzel, Maša, mag. farm. | 34373 |
Serša, Gregor | 08800 |
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