-
Sarcopenia in patients with heart failure with preserved ejection fraction: Impact on muscle strength, exercise capacity and quality of lifeBekfani, Tarek ...Background. To describe the prevalence of sarcopenia in ambulatory patients with heart failure with preserved ejection fraction (HFpEF) and its relation to reduced exercise capacity, muscle strength, ... and quality of life (QoL). Methods and results. A total of 117 symptomatic outpatients with HFpEF were prospectively enrolled in Germany, England, and Slovenia as part of the Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF). Appendicular skeletal muscle (ASM) mass (the sum of muscle mass in both arms and legs) was assessed by DEXA. Echocardiography, 6-minute walk testing (6-MWT), muscle strength assessment, spiroergometry and QoL evaluation using EQ-5D Questionnaire were performed. Sarcopenia was defined as ASM 2 standard deviations below the mean of a healthy reference group aged 18-40 years. Patients were divided into 3 groups according to the E/e' value: < 8, 9-14, and > 15. Sarcopenia was detected in 19.7% of all patients. These patients performed worse during 6-MWT (404 +/- 116 vs. 307 +/- 145 m, p = 0.003) and showed lower absolute peak oxygen consumption (1579 +/- 474 vs. 1211 +/- 442 mL/min, p < 0.05). Both ASM and muscle strength were lowest in patients with E/e' > 15 (p < 0.05). Higher values of muscle strength/ASM were associated with a better QoL (r = 0.5, p < 0.0005). Logistic regression showed ASM to be independently associated with reduced distance walked during the 6-MWT adjusted for NYHA, height, left atrium diameter, ferritin and forced expiratory volume in 1 s (FEV1) (odds ratio 1.2, p = 0.02). Conclusion. Sarcopenia affects a clinically relevant proportion of patients with HFpEF. Low ASM is strongly linked to reduced muscle strength, exercise capacity and QoL in these patients.Source: International journal of cardiology. - ISSN 0167-5273 (Letn. 222, št. 1 November 2016, 2016, str. 41-46)Type of material - article, component partPublish date - 2016Language - englishCOBISS.SI-ID - 764323
Author
Bekfani, Tarek |
Pellicori, Pierpaolo |
Morris, Daniel A. |
Ebner, Nicole |
Valentova, Miroslava |
Steinbeck, Lisa |
Wachter, Rolf |
Elsner, Sebastian |
Sliziuk, Veronika |
Schefold, Joerg C. |
Lainščak, Mitja
Topics
Heart failure |
Sarcopenia |
Exercise tolerance |
Quality of life |
Popuščanje srca |
Sarkopenija |
Telesna zmogljivost |
Kakovost življenja
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Bekfani, Tarek | ![]() |
Pellicori, Pierpaolo | ![]() |
Morris, Daniel A. | ![]() |
Ebner, Nicole | ![]() |
Valentova, Miroslava | ![]() |
Steinbeck, Lisa | ![]() |
Wachter, Rolf | ![]() |
Elsner, Sebastian | ![]() |
Sliziuk, Veronika | ![]() |
Schefold, Joerg C. | ![]() |
Lainščak, Mitja | 22680 |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.