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Safety and efficacy of the feed additives concentrated liquid L-lysine (base) and L-lysine monohydrochloride produced by Corynebacterium glutamicum KCCM 80183 for all animal species (CJ Europe GmbH) [Elektronski vir]EFSA Panel on Additives and Products or Substances used in Animal Feed (Parma)Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on concentrated liquid ... l-lysine (base) and l-lysine monohydrochloride (HCl) produced using Corynebacterium glutamicum KCCM 80183 when used as nutritional additives in feed and water for drinking for all animal species. The active substance is l-lysine. Concentrated liquid l-lysine (base) and l-Lysine HCl produced by the strain C. glutamicum KCCM 80183 do not pose any safety concern as regards the genetic modification of the production strain. The use of the additives under assessment in supplementing feed to compensate for l-lysine deficiency in feedingstuffs is safe for the target species. The FEEDAP Panel has concerns about the use of amino acids in water for drinking for hygienic reasons, and due to the risk of imbalances when administered simultaneously via feed. The use of both forms of l-lysine produced by fermentation using C. glutamicum KCCM 80183 in animal nutrition is considered safe for the consumers and for the environment. Concentrated liquid l-lysine (base) produced by C. glutamicum KCCM 80183 is considered hazardous by inhalation, not irritant to skin and eyes and it is not a skin sensitiser. l-Lysine HCl produced by C. glutamicum KCCM 80183 is considered hazardous by inhalation, it is not irritant to skin but mildly irritant to eyes and it is not a skin sensitiser. The additives under assessment are considered as efficacious sources of the essential amino acid l-lysine for non-ruminant animal species. For the supplemental l-lysine to be as efficacious in ruminants as in non-ruminant species, it would require protection against degradation in the rumen.Source: EFSA journal [Elektronski vir]. - ISSN 1831-4732 (6537, Vol. 19, Iss. 4, Apr. 2021, 16 str.)Type of material - e-articlePublish date - 2021Language - englishCOBISS.SI-ID - 76917507
Author
Bampidis, Vasileios |
Azimonti, Giovanna |
Bastos, Maria de Lourdes |
Christensen, Henrik |
Dusemund, Birgit |
Durjava, Mojca |
Kouba, Maryline |
López-Alonso, Marta |
López Puente, Secundino |
Marcon, Francesca |
Mayo, Baltasar |
Pechová, Alena |
Petkova, Mariana |
Ramos, Fernando |
Sanz, Yolanda |
Villa, Roberto Edoardo |
Woutersen, Ruud |
Anguita, Montserrat |
Galobart, Jaume |
Holczknecht, Orsolya |
Manini, Paola |
Pettenati, Elisa |
Pizzo, Fabiola |
Tarrés-Call, Jordi |
EFSA Panel on Additives and Products or Substances used in Animal Feed |
Parma
Topics
L-lysine monohydrochloride |
concentrated liquid L-lysine (base) |
Corynebacterium glutamicum |
nutritional additive |
efficacy |
safety |
L-lizin monohidroklorid |
koncentriran tekoči L-lizin (baza) |
prehranski dodatki |
učinkovitost |
varnost |
vitamini in pro-vitamini
Shelf entry
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Bampidis, Vasileios | |
Azimonti, Giovanna | |
Bastos, Maria de Lourdes | |
Christensen, Henrik | |
Dusemund, Birgit | |
Durjava, Mojca | 21878 |
Kouba, Maryline | |
López-Alonso, Marta | |
López Puente, Secundino | |
Marcon, Francesca | |
Mayo, Baltasar | |
Pechová, Alena | |
Petkova, Mariana | |
Ramos, Fernando | |
Sanz, Yolanda | |
Villa, Roberto Edoardo | |
Woutersen, Ruud | |
Anguita, Montserrat | |
Galobart, Jaume | |
Holczknecht, Orsolya | |
Manini, Paola | |
Pettenati, Elisa | |
Pizzo, Fabiola | |
Tarrés-Call, Jordi |
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