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Proučevanje sestave, lastnosti in tehnologije izdelave nanodostavnih sistemov za mRNA-cepiva = Investigation of composition, properties and production procedure of nanodelivery systems for mRNA-based vaccines : magistrski študijski program Industrijska farmacijaOjsteršek, AdrijanaCepiva na osnovi informacijske RNA (mRNA) predstavljajo obetavno platformo v boju proti virusnim okužbam in v imunoterapiji raka. Nanodostavni sistemi imajo pomembno vlogo v mRNA-cepivih, saj ... omogočajo vnos mRNA v celice in lahko delujejo kot adjuvansi. Namen te magistrske naloge je bil na podlagi razpoložljivih literaturnih virov proučiti sestavo, tehnologijo izdelave in lastnosti nanodostavnih sistemov, ki omogočajo vnos mRNA-cepiv. Ugotovili smo, da so v izbranih raziskavah proučevali štiri vrste nanodostavnih sistemov za vnos mRNA-cepiv, in sicer lipidne, polimerne, peptidne ter hibridne nanodostavne sisteme. Primerjali smo njihovo sestavo, velikost, porazdelitev velikosti, površinski naboj, učinkovitost vgrajevanja mRNA in imunski odziv, ki ga sprožijo in vitro ali in vivo. Ugotovili smo, da so se v raziskavah najpogosteje pojavili lipidni nanodostavni sistemi, natančneje lipidni nanodelci. Večina nanodostavnih sistemov je imela ozko porazdelitev velikosti delcev. Vsi prazni nanodostavni sistemi so imeli pozitiven površinski naboj, po vgrajevanju mRNA pa se je njihov površinski naboj zmanjšal, kar je vodilo v fizikalno manj stabilne formulacije. Rezultati transmisijske elektronske mikroskopije so pokazali, da so bili vsi nanodostavni sistemi sferične oblike z ozko porazdelitvijo velikosti. Vse formulacije so sprožile močne imunske odzive in vivo ali in vitro, kar kaže njihov potencial za uporabo v mRNA-cepivih. Na podlagi pregleda literature smo zaključili, da so glede na lastnosti najbolj obetavni za uporabo v mRNA-cepivih lipidni nanodostavni sistemi, saj so stabilni, varni, zahtevajo relativno nizke stroške izdelave in so tudi najbolj raziskovani.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [A. Ojsteršek], 2021Language - slovenianCOBISS.SI-ID - 78836227
Author
Ojsteršek, Adrijana
Other authors
Kocbek, Petra, farmacevtka
Topics
Dostavni sistemi |
Cepiva |
Nanotehnologija |
cepiva |
covid-19 |
lipidni nanodelci |
nanodostavni sistemi |
mRNA
Library/institution |
City | Acronym | For loan | Other holdings |
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Faculty of Pharmacy, Ljubljana | Ljubljana | FFALJ |
reading room 1 cop.
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Ojsteršek, Adrijana | |
Kocbek, Petra, farmacevtka | 24402 |
Source: Personal bibliographies
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