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Separation of parthenolide from Tanacetum parthenium
Čretnik, Lucija ...
In present work the extraction of Tanacetum parthenium flower heads was performed using supercritical carbon dioxide at pressures from 200 bar to 800 bar and at temperatures 40 °e, 60 °e and 80 °e. ...For comparison, the conventional extractions with organic solvents and water have been made. Dried Tanacetum parthenium flower heads were used as starting material. Supercritical fluid extraction was performed using a semicontinuous flow apparatus. In order to fractionate the waxy and active components the separation was performed in two steps. The results showed that generally the parthenolide yield increases with increasing pressure and is in the range from approximately 100 to 330 mg/l OO g dry material. The extraction yields obtained by conventional solvent extractions of dried material are similar or even higher than those resulting from supercritical fluid extractions. The highest parthenolide yield using conventional extractions was achieved using methanol as solvent and was 763.6 mg/l OO g dry material.
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