This paper describes an integrated MINLP synthesis of overall process schemes using a combined synthesis / analysis approach. The synthesis is carried out by a multilevel hierarchical MINLP ...optimization of the flexible superstructure, whilst the analysis is performed in an economic attainable region (EAR). The role of the MINLP synthesis step is to obtain a feasible and optimal process structure, and the role of the subsequent EAR analysis stepis to verify the MINLP solution and to propose in the feedback loop, any profitable superstructure modifications for the next MINLP. The main objective of the integrated synthesis is to exploit interactions between the reactor network, separator network and the remaining part of the heat/energy integrated process scheme.
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