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Phase II study of fluorouracil, leucovorin and interferon alpha-2a in patients with advanced colon cancer = Zdravljenje bolnikov z metastatskim rakom širokega črevesa s fluorouracilom, levkovorinom in interferonom alfa-2aŠtabuc, Borut ...Based on in viro studies that have demonstrated synergy between fluorouracil (5-FU) and leucovorin (LV) as well as between 5-FU and recombinant alpha-2a interferon (IFN) against colon cancer cell ... lines a phase II study was carried out to evaluate the toxicity and clinical activity of 5-FU modulated with LV and IFN in patients with metastatic colon cancer. Twenty-two chemotherapy naive patients with measurable metastases of colon cancer have been treated with daily doses of 5-FU 600 mg/m2 in 6-hr intravenous infusion, and of LV 20 mg/m2 intravenously and IFN 6 MU subcutaneously, for 5 days every 4 weeks. Median age was 60 years, median PS (ECOG) was 1 (range 0-2). Liver, soft tissue and lung metastases were found in 12, 5 and 8 patients, respectively. Nineteen patients had a single metastatic site, two double, whereas one had more than two metastatic sites. Patients had 2-9 (mean 5) cycles of treatment.Objective response was observed in 7 patients (32%), and stable disease in 7 patients (32%). Overall median survival was 12.5 months, and for responders 14.4 months. Responses were generally short and median time for progression was 5.5 months. The most frequent adverse reactions were flu-like syndrome (50%), nausea/vomiting (36%), diarhoea (13Č), stomatitis (27%) and leucopenia (13%). This regimen of 5-FU with LV and IFN administration does notappear to be superior to previously published shedules of 5-FU with IFN or 5-FU with LV.Source: Radiology and oncology. - ISSN 1318-2099 (Letn. 32, št. 4, 1998, str. 407-415)Type of material - article, component partPublish date - 1998Language - englishCOBISS.SI-ID - 8142809
Author
Štabuc, Borut |
Markovič, Aleksandra |
Brecelj, Erik |
Bešlija, Samir |
Cizej, Tomaž-Edvard
Topics
Colonic neoplasms |
Drug therapy |
Fluorouracil |
Therapeutic use |
Leucovorin |
Therapeutic use |
Interferon alfa-2a |
Therapeutic use |
Clinical trials, phase ii |
Drug therapy, combination |
Survival analysis
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Štabuc, Borut | 11949 |
Source: Personal bibliographies
and: SICRIS
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