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  • Clinical aspects of rejection and treatment
    Buturović-Ponikvar, Jadranka ; Kandus, Aljoša
    The main clinical sign of kidney graft rejection is deterioration of renal function, usually assessed as the rise in serum creatinine in everyday clinical work. Today, in the era of potent ... immunossuppressive drugs systemic symptoms of rejection occur rarely. Renal core biopsy is the standard procedure for diagnosi of rejection and is usually perofmed after all other possible causes of graft failure are excluded (vascular problems, urinary tract obstruction and leak, hypovolemia). Ultrasound-Doppler examination of renal transplant is the first step in diagnostic work-up, other imaging studies (scintigraphy, angiography etc.) being used if necessary. Methylprednisolone pulses therapy for 3-5 days is the standard therapeutic approach and can be started before histopathologic results are available. If there is no satisfactory response to steroids proceedings to antilymphocyte agents is necessary, either as monoclonal (OKT3) or polycloncal antilymphocyteagents. For particular severe of vascular rejection OKT-3 may bethe best first-line option.
    Type of material - conference contribution
    Publish date - 1998
    Language - english
    COBISS.SI-ID - 8573913