-
Correlation guided Network Integration (CoNI) reveals novel genes affecting hepatic metabolism [Elektronski vir]Klaus, Valentina S. ...Objective Technological advances have brought a steady increase in the availability of various types of omics data, from genomics to metabolomics. Integrating these multi-omics data is a chance and ... challenge for systems biology; yet, tools to fully tap their potential remain scarce. Methods We present here a fully unsupervised and versatile correlation-based method – termed Correlation guided Network Integration (CoNI) – to integrate multi-omics data into a hypergraph structure that allows for the identification of effective modulators of metabolism. Our approach yields single transcripts of potential relevance that map to specific, densely connected, metabolic subgraphs or pathways. Results By applying our method on transcriptomics and metabolomics data from murine livers under standard Chow or high-fat diet, we identified eleven genes with potential regulatory effects on hepatic metabolism. Five candidates, including the hepatokine INHBE, were validated in human liver biopsies to correlate with diabetes-related traits such as overweight, hepatic fat content, and insulin resistance (HOMA-IR). Conclusion Our method's successful application to an independent omics dataset confirmed that the novel CoNI framework is a transferable, entirely data-driven, flexible, and versatile tool for multiple omics data integration and interpretation.Source: Molecular metabolism. - ISSN 2212-8778 (Vol. 53, Nov. 2021, str. 1-15)Type of material - e-article ; adult, seriousPublish date - 2021Language - englishCOBISS.SI-ID - 88232707
Author
Klaus, Valentina S. |
Schriever, Sonja C. |
Monroy Kuhn, José Manuel |
Peter, Andreas |
Irmler, Martin |
Tokarz, Janina |
Prehn, Cornelia |
Kastenmüller, Gabi |
Beckers, Johannes |
Adamski, Jerzy, molekularna biologija
Topics
integracija podatkov |
steatoza jeter |
sistemska biologija |
data integration |
hepatic steatosis |
systems biology
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Klaus, Valentina S. | ![]() |
Schriever, Sonja C. | ![]() |
Monroy Kuhn, José Manuel | ![]() |
Peter, Andreas | ![]() |
Irmler, Martin | ![]() |
Tokarz, Janina | ![]() |
Prehn, Cornelia | ![]() |
Kastenmüller, Gabi | ![]() |
Beckers, Johannes | ![]() |
Adamski, Jerzy, molekularna biologija | 55378 |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.