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Heterogeneous response of airway eosinophilia to anti-IL-5 biologics in severe asthma patients [Elektronski vir]Kopač, Maruša ...Many questions concerning responders (R) and nonresponders (NR) in severe eosinophilic asthma (SEA) after blocking the IL-5 (interleukin 5) pathway are still not clear, especially regarding the early ... parameters of response to biologics in personalized treatment strategies. We evaluated 17 SEA patients treated with anti-IL-5 biologics (16 patients mepolizumab, one patient benralizumab) before the introduction of biologics, and at a week 16 follow-up. Clinical, cellular and immunological parameters in peripheral blood were measured in R and NR. Sputum induction with the measurement of cellular and immunological parameters was performed at 16 weeks only. There were 12 R and 5 NR to biologics. After 16 weeks, there was a significant improvement in percentages of FEV1 (p = 0.001), and asthma control test (ACT) (p = 0.001) in the R group, but not in NR. After 16 weeks, the eosinophils in induced sputum were 27.0% in NR and 4.5% in R (p = 0.05), with no difference in IL-5 concentrations (p = 0.743). Peripheral eosinophilia decreased significantly in NR (p = 0.032) and R (p = 0.002). In patients with SEA on anti-IL-5 therapy, there was a marked difference in airway eosinophilic inflammation between R and NR already at 16 weeks, after anti-IL-5 introduction.Source: Journal of personalized medicine [Elektronski vir]. - ISSN 2075-4426 (Vol. 12, iss. 1, 2022, str. 1-12)Type of material - e-article ; adult, seriousPublish date - 2022Language - englishCOBISS.SI-ID - 92821507
Author
Kopač, Maruša |
Rijavec, Matija |
Korošec, Peter, 1970- |
Bidovec, Urška |
Kern, Izidor |
Vantur, Romana |
Škrgat, Sabina
Topics
težka astma |
anti-IL-5 biološka zdravila |
eozinofilija |
dihalne poti |
sputum
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Kopač, Maruša | |
Rijavec, Matija | 29300 |
Korošec, Peter, 1970- | 22807 |
Bidovec, Urška | 25169 |
Kern, Izidor | 15781 |
Vantur, Romana | 39238 |
Škrgat, Sabina | 25178 |
Source: Personal bibliographies
and: SICRIS
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