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Mixture design of theophylline retard formulation
Kristl, Albin ...
Three different cellulose derivatives (hydroxypropyl cellulose (HPC), hydroxypropyl methyl cellulose (HPMC) and microcrystalline cellulose (MC) wereused to prepare 10% of thephylline with the aid of ...wet granulation. The retardation effevt of different compositions of these cellulose derivatives was investigated. Using mixture design, the formulations with the best retardation properties were selected. On the basis of these results, tablets with different compositions containing 60% (300 mg) of thephylline were prepared. The simulation was performed on a personal computer with the implemented digital simulation language SIMCOS to predict steady-state plasma levels. It was established that formulation C, composed of 34,6% of MC, 4,7% of HPMC, 0,7% of HPC and 60% of thephylline in vivo the same retardation effect as commercially available theophylline tablets.
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