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The role of vitamin A in retinal diseases [Elektronski vir]Sajovic, Jana ...Vitamin A is an essential fat-soluble vitamin that occurs in various chemical forms. It is essential for several physiological processes. Either hyper- or hypovitaminosis can be harmful. One of the ... most important vitamin A functions is its involvement in visual phototransduction, where it serves as the crucial part of photopigment, the first molecule in the process of transforming photons of light into electrical signals. In this process, large quantities of vitamin A in the form of 11-cis-retinal are being isomerized to all-trans-retinal and then quickly recycled back to 11-cis-retinal. Complex machinery of transporters and enzymes is involved in this process (i.e., the visual cycle). Any fault in the machinery may not only reduce the efficiency of visual detection but also cause the accumulation of toxic chemicals in the retina. This review provides a comprehensive overview of diseases that are directly or indirectly connected with vitamin A pathways in the retina. It includes the pathophysiological background and clinical presentation of each disease and summarizes the already existing therapeutic and prospective interventions.Source: International journal of molecular sciences [Elektronski vir]. - ISSN 1422-0067 (Vol. 23, iss. 3, 2022, str. 1-27)Type of material - e-article ; adult, seriousPublish date - 2022Language - englishCOBISS.SI-ID - 97200131
Author
Sajovic, Jana |
Meglič, Andrej, 1980- |
Glavač, Damjan |
Markelj, Špela |
Hawlina, Marko |
Fakin, Ana
Topics
vitamin A |
retinal diseases |
ABCA4 |
vitamin A |
bolezni mrežnice |
ABCA4
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Sajovic, Jana | 53566 |
Meglič, Andrej, 1980- | 25511 |
Glavač, Damjan | 09275 |
Markelj, Špela | 54473 |
Hawlina, Marko | 09154 |
Fakin, Ana | 33340 |
Source: Personal bibliographies
and: SICRIS
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