Faculty of Pharmacy, Lj. (FFALJ)
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Izbor metod za določevanje fizikalnih lastnosti koloidnih sistemov v farmaciji = The selection of methods to determine physical properties of colloidal systems used in pharmacyPodlogar, Filip ; Gašperlin, MirjanaEden izmed ciljev farmacevtske tehnologije je izbrati ustrezen nosilni sistem za dostavo izbrane uèinkovine na mesto delovanja. Vse pomembnejsi postajajo vehikli, ki zmorejo ciljano dostavljati ... molekule ali pa omogoèajo nadzorovano sprosèanje uèinkovine. V sodobni farmaciji se kot potencialni vehikli za dostavo uèinkovin vedno pogosteje pojavljajo koloidni sistemi, predvsem mikroemulzije, liposomi in nanodelci. Res pa je, da na trgu se ni prisotnih veliko industrijsko izdelanih farmacevtskih oblik, ki bi izkorisèale njihove prednosti. Da bi lahko naèrtovali in predvidevali lastnosti posameznih nosilnih sistemov ter farmacevtske oblike uspesno optimirali, je potrebno poznati fizikalne lastnosti doloèenega sistema, metode doloèanja le-teh ter pomen ustreznih parametrov. Fizikalne lastnosti niso edine pomembne, so pa velikokrat kljuène za obnasanje taksnih sistemov v in vitro ali in vivo okolju. Èlanek podaja pregled tehnik za fizikalno karakterizacijo koloidnih sistemov s poudarkom na doloèitevi velikosti delcev ali struktur. Kot ilustracijo navajamo tudi nekatere praktiène primere doloèanja fizikalnih lastnosti mikroemulzijSource: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Let. 54, št. 1, 2003, str. 47-56)Type of material - article, component partPublish date - 2003Language - slovenianCOBISS.SI-ID - 1259889
Author
Podlogar, Filip |
Gašperlin, Mirjana
Topics
koloidni sistemi |
mikroemulzije |
liposomi |
fizikalne lastnosti |
velikost delcev
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source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Let. 54, št. 1, 2003, str. 47-56)
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