Faculty of Pharmacy, Lj. (FFALJ)
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Vpliv vrste stabilizatorja na izdelavo mikrosfer z metodo odparevanja topila = The influence of stabilizer type on microspheres preparation by solvent evaporation method : diplomska nalogaZavrl, SamoMetoda priprave mikrosfer z odparevanjem topila omogoèa modifikacijo stevilnihparametrov in na ta naèin pripravo mikrosfer razliènih lastnosti. V nasi raziskavi smo poskusali ugotoviti, kako na ... nastanek in lastnosti mikrosfer vpliva vrsta uporabljenega stabilizatorja in vrsta ogrodnega polimera. V ta namen smo izdelovali mikrosfere razliènih Eudragitov z metodo odparevanja topila s tremi kationskimi (dimetildioktadecilamonijev bromid, heksadecilpiridinijev klorid, dodeciltrimetilamonijev bromid) in tremi anionskimi stabilizatorji (magnezijev stearat, natrijev heksadekansulfonat, natrijev laurilsulfat) ter s Spanoma 20 (sorbitan monolaurat) in 80 (sorbitan monooleat) kot neionskima stabilizatorjema. Kot ogrodni polimer smo uporabili sest razliènih poli(met)akrilatnih estrov (Eudragit E, RS, RL, L, L 55 in S). Zunanjo fazo je predstavljal tekoèi parafin z dispergiranim stabilizatorjem, notranjo pa v acetonu raztopljen polimer. Z namenom, da izkljuèimo morebitne vplive uèinkovine, smo se odloèili, da v mikrosfere ne bomo vgrajevali uèinkovine. V primeru nastanka mikrosfer smo le-tem doloèili povpreène velikosti in sirino distribucije velikosti ter mikrosfere po velikostih frakcijah pregledali z optiènim mikroskopom. Rezultati so pokazali, da je za nastanek zelo pomembna pravilna izbira stabilizatorja. Mikrosfere smo uspesno izolirali le z uporabo treh stabilizatorjev, katerim je skupna daljsa stranskaveriga z 18 oziroma 16 C atomi. Mikrosfer Eudragitov S in L 55 nam ni uspelo izolirati. Z merjenjem stiènih kotov tekoèega parafina na stabilizatorju smo pokazali, da je ta kot pri stabilizatorjih, s katerimi smo uspesno izolirali mikrosfere, nad 68°. S stabilizatorji, ki imajo stièni kot tekoèega parafina na stabilizatorju manjsi od 68°, nam mikrosfer ni uspelo izdelati. Pokazali smo, da velikost izdelanih mikrosfer narasèa z narasèanjem stiènega kota. Najveèje mikrosfere smo pripravili z natrijevim heksadekansulfonatom, le-te mikrosfere pa so tudi najbolj nepravilnih oblik. Ob primerjavi posameznih vplivov smo ugotovili, da ima na povpreèno velikost izdelanih mikrosfer iz Eudragitov E, RS in RL mnogo veèji vpliv vrsta uporabljenega stabilizatorja kot pa viskoznost notranje faze.Type of material - undergraduate thesis ; adult, seriousPublication and manufacture - Ljubljana : [Zavrl, S.], 2004Language - slovenianCOBISS.SI-ID - 1531505
Author
Zavrl, Samo
Other authors
Bogataj, Marija, 1963- |
Mateović, Tatjana
Topics
mikrosfere |
eudragiti |
struktura |
testi |
priprava mikrosfer |
vrednotenje
Call number – location, accession no. ... |
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Knjižnica dp 0000000615 Zavrl, Samo Vpliv IN: 0007642 Knjižnica dp 615 Zavrl, Samo Vpliv IN: 0007642 |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Zavrl, Samo | |
Bogataj, Marija, 1963- | 11124 |
Mateović, Tatjana | 21457 |
Source: Personal bibliographies
and: SICRIS
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