Faculty of Pharmacy, Lj. (FFALJ)
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Serumske vrednosti bilirubina pri bolnikih z multiplo sklerozo = Serum bilirubin in patients with multiple sclerosis : sistematični pregled in meta-analiza : systematic review and meta-analysisBrkinjač, ŠpelaMultipla skleroza (MS) je kronična avtoimunska bolezen osrednjega živčnega sistema, kjer je najbolj prizadeta bela možganovina. Pri MS imunski sistem začne napadati mielin, ki predstavlja zaščitno ... plast okoli aksonov živčnih celic. V osrednjem živčnem sistemu se zaradi vnetnih procesov, ki spremljajo bolezen, tvorijo povečane količine reaktivnih kisikovih zvrsti. V našem raziskovalnem delu smo preučevali vpliv MS in z MS povezanih bolezenskih stanj na serumske vrednosti bilirubina. Bilirubin je močan endogeni antioksidant s protivnetnim in protitrombotičnim delovanjem. Namen magistrske naloge bo s pomočjo sistematičnega pregleda literature in meta analize preučiti zvezo med serumskimi koncentracijami bilirubina in multiplo sklerozo. Sistematični pregled literature smo izvedli v petih različnih podatkovnih bazah, in sicer PubMed (Medline), Web of Science, Clinical Trials, Cochrane Library in Google Scholar. Meta-analizo smo izvajali v programskem okolju R (paket meta) in rezultate posameznih analiz prikazali s pomočjo drevesnih diagramov. Naredili smo 3 sklope analiz, in sicer: primerjava serumskih vrednosti BLR pri bolnikih z MS v primerjavi z zdravimi posamezniki, primerjava serumskih vrednosti BLR pri bolnikih z MS povezanimi bolezenskimi stanji (ON/NMO/CIS) v primerjavi z zdravimi posamezniki in primerjava serumskih vrednosti BLR med spoloma pri bolnikih z MS v primerjavi z zdravimi posamezniki. Pri vseh treh sklopih smo primerjali vrednosti celokupnega bilirubina (Tbil), direktnega bilirubina (Dbil) in indirektnega bilirubina (Ibil). Rezultati kažejo, da imajo bolniki z MS nižje vrednosti BLR v primerjavi z zdravimi posamezniki. Med bolniki z ON/NMO/CIS in zdravimi posamezniki te razlike ni. Med spoloma pri bolnikih z MS ni statistično značilnih razlik, čeprav imata oba spola bolnikov z MS nižje vrednosti bilirubina v primerjavi z zdravimi posamezniki. S tem lahko potrdimo našo hipotezo o znižanih serumskih vrednostih BLR pri bolnikih z MS. Bolniki z MS imajo nižje serumske vrednosti bilirubina, zato se odpira potencialna možnost uporabe dolgoročnega spremljanja serumskih vrednosti bilirubina pri napredovanju bolezni in/ali ocenjevanju uspešnosti farmakološkega zdravljenja.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [Š. Brkinjač], 2024Language - slovenianCOBISS.SI-ID - 199073795
Author
Brkinjač, Špela
Other authors
Žiberna, Lovro |
Locatelli, Igor
Topics
Multipla skleroza |
bilirubin |
nevromielitis vidnega živca |
optični nevritis |
klinično izoliran sindrom |
antioksidativna zaščita
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Knjižnica emšf 0000000616 BRKINJAČ ŠPELA Serumske 0000001398 IN: 0018187 Knjižnica emšf 616 BRKINJAČ ŠPELA Serumske 1398 IN: 0018187 |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Brkinjač, Špela | ![]() |
Žiberna, Lovro | 29416 |
Locatelli, Igor | 24399 |
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