Faculty of Pharmacy, Lj. (FFALJ)
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The manufacturing techniques of drug-loaded polymeric nanoparticles from preformed polymersAhlin Grabnar, Pegi ; Kristl, JulijanaOver the past few decades, nanoparticle (NP) formulation has been the subject of extensive research. The choice of a suitable NP formulation technique is dependent on the physicochemical properties ... of the drug, such as solubility and chemical stability. Different NP manufacturing methods enable modification of the physicochemical characteristics such as size, structure, morphology and surface texture, but also affect the drug loading, drug entrapment efficiency and release kinetics. This review covers an update on the state of art of the manufacturing of polymeric NPs from preformed polymers. Both, conventional methods for NP preparation, such as spontaneous formulation and emulsification-based methods, and new approaches in NP technology are presented. A comparative analysis is given for polymer, drug and solvent nature, toxicity, purification, drug stability and scalability of the method. The information obtained allows establishing criteria for selecting a method for preparation of NPs according to its advantages and limitations.Source: Journal of microencapsulation. - ISSN 0265-2048 (Vol. 28, no. 4, 2011, str. 323-335)Type of material - article, component partPublish date - 2011Language - englishCOBISS.SI-ID - 3006065
Author
Ahlin Grabnar, Pegi |
Kristl, Julijana
Topics
nanodelci |
polimeri |
dostavnost zdravil |
oblikovanje zdravil
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Ahlin Grabnar, Pegi | 15490 |
Kristl, Julijana | 09032 |
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