Faculty of Pharmacy, Lj. (FFALJ)
-
In silico discovery of novel potent antioxidants on the basis of pulvinic acid and coumarine derivatives and their experimental evaluation [Elektronski vir]Martinčič, Rok ...A pigment from the edible mushroom Xerocomus badius norbadione A, which is a natural derivative of pulvinic acid, was found to possess antioxidant properties. Since the pulvinic acid represents a ... novel antioxidant scaffold, several other derivatives were recently synthe- tized and evaluated experimentally, along with some structurally related coumarine deriva- tives. The obtained data formed the basis for the construction of several quantitative structure-activity and pharmacophore models, which were employed in the virtual screening experiments of compound libraries and for the prediction of their antioxidant activity, with the goal of discovering novel compounds possessing antioxidant properties. A final prioriti- zation list of 21 novel compounds alongside 8 established antioxidant compounds was created for their experimental evaluation, consisting of the DPPH assay, 2-deoxyribose assay, ß-carotene bleaching assay and the cellular antioxidant activity assay. Ten novel com- pounds from the tetronic acid and barbituric acid chemical classes displayed promising anti- oxidant activity in at least one of the used assays, that is comparable to or even better than some standard antioxidants. Compounds 5 , 7 and 9 displayed good activity in all the assays, and were furthermore effective preventers of oxidative stress in human peripheral blood mononuclear cells, which are promising features for the potential therapeutic use of such compounds.Source: PloS one [Elektronski vir]. - ISSN 1932-6203 (Vol. 10, no. 10, 2015, str. 1-27, e0140602)Type of material - e-articlePublish date - 2015Language - englishCOBISS.SI-ID - 3958129
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Martinčič, Rok | 34547 |
Mravljak, Janez | 23419 |
Švajger, Urban | 26198 |
Perdih, Andrej, farmacevt, 2.9.1980- | 25493 |
Anderluh, Marko | 21456 |
Novič, Marjana | 09775 |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location: