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Novel magnetic iron oxide-dextran sulphate nanocomposites as potential anticoagulants: Investigating interactions with blood components and assessing cytotoxicity [Elektronski vir]Plohl, Olivija ...Examining the critical role of anticoagulants in medical practice, particularly their central function in preventing abnormal blood clotting, is of the utmost importance. However, the study of ... interactions between blood proteins and alternative anticoagulant nano-surfaces is still understood poorly. In this study, novel approach involving direct functionalisation of magnetic iron oxide nanoparticles (MNPs) as carriers with sulphated dextran (s-dext) is presented, with the aim of evaluating the potential of magnetically-responsive MNPs@s-dext as anticoagulants. The physicochemical characterisation of the synthesised MNPs@s-dext includes crystal structure analysis, morphology study, surface and electrokinetic properties, thermogravimetric analysis and magnetic properties` evaluation, which confirms the successful preparation of the nanocomposite with sulfonate groups. The anticoagulant potential of MNPs@s-dext was investigated using a standardised activated partial thromboplastin time (APTT) test and a modified APTT test with a quartz crystal microbalance with dissipation (QCM-D) which confirmed the anticoagulant effect. Time-resolved solid-liquid interactions between the MNPs@s-dext and model blood proteins bovine serum albumin and fibrinogen were also investigated, to gain insight into their hemocompatibility, and revealed protein-repellence of MNPs@s-dext against blood proteins. The study also addressed comprehensive cytotoxicity studies of prepared nanocomposites, and provided valuable insights into potential applicability of MNPs@s-dext as a promising magnetic anticoagulant in biomedical contexts.Source: Carbohydrate polymers [Elektronski vir]. - ISSN 1879-1344 (Vol. 343, [article no.] 122469, Nov. 2024, 13 str.)Type of material - e-article ; adult, seriousPublish date - 2024Language - englishCOBISS.SI-ID - 202837507
Author
Plohl, Olivija |
Fras Zemljič, Lidija |
Vihar, Boštjan |
Vesel, Alenka |
Gyergyek, Sašo |
Maver, Uroš, 1983- |
Ban, Irena |
Bračič, Matej, 1981-
Topics
dekstran sulfat |
magnetni nanodelci |
interakcije krvnih beljakovin |
nastajanje strdkov |
antikoagulanti |
študije citotoksičnosti |
dextran sulphate |
magnetic nanoparticles |
blood protein interactions |
clot formation |
anticoagulants |
cytotoxicity studies
Author | Plohl, Olivija ... |
Title | Novel magnetic iron oxide-dextran sulphate nanocomposites as potential anticoagulants: Investigating interactions with blood components and assessing cytotoxicity [Elektronski vir] |
Publication date | 2024-07-14 |
COBISS.SI-ID | 202837507 |
Publication version in repository | Publisher's version |
Publication licence | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International |
Embargo | Immediate publication for public |
Project(s) from which the publication was funded
Title | Acronym | Project ID | Funder |
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Tekstilna kemija in napredni tekstilni materiali | P2-0118-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Tankoplastne strukture in plazemsko inženirstvo površin | P2-0082-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Razvoj visokoobčutljive elektrokemijske metode na osnovi magnetnih polimernih nanokompozitov za določanje spojin antibiotikov v sledovih v okolijskih sistemih | J1-4416-2022 |
Javna agencija za znanstvenoraziskovalno in inovacijsko dejavnost Republike Slovenije |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Plohl, Olivija | 35476 |
Fras Zemljič, Lidija | 19753 |
Vihar, Boštjan | 50121 |
Vesel, Alenka | 20048 |
Gyergyek, Sašo | 26478 |
Maver, Uroš, 1983- | 30850 |
Ban, Irena | 08761 |
Bračič, Matej, 1981- | 37632 |
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