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Pomen endotelijske disfunkcije za razvoj pljučne arterijske hipertenzije in nove možnosti zdravljenja = The importance of endothelial dysfunction for the development of pulmonary arterial hypertension and new therapeutic optionsSalobir, Barbara, 1966- ; Šabovič, Mišo ; Praprotnik, SonjaBackground. Pulmonary arterial hypertension may exist as a primary condition or as a secondary condition, most commonly with collagen vascular disease. Patients with pulmonary arterial hypertension ... usually have bad prognosis as the effectiveness of conventional treatment is poor New knowledge about importance of endothelial dysfunction in development of pulmonary arterial hypertension has opened a wide field of possible new treatment options. Conclusions. Endothelial dysfunction in pulmonary vascular bed is characterised by an inappropriate release of vasoactive substances from endothelium producing vasoconstriction, remodeling of arterial wall and increased local tendency for thrombosis. Several new drugs have been already tested in clinical case-controlled studies: prostacyclin and its analogues applied intravenously or in inhalations, inhaled nitric oxide and drugs which increase nitric oxide concentration such as sildenafil aud l-arginine, endothelin receptors antagonists in tablets and tromboxane antagonist in tablets. Only tromboxane antagonist was shown to be ineffective whereas all other drugs were effective at least in certain subgroups of patients. New clinical trials will give answer not only in respect to the comparative efficacy of the drugs meutioued earlier and their combinations but also to therecognition of factors that determine the success of treatment in individual patient.Source: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 72, št. 6, jun. 2003, str. 381-385)Type of material - article, component partPublish date - 2003Language - slovenianCOBISS.SI-ID - 16589017
Author
Salobir, Barbara, 1966- |
Šabovič, Mišo |
Praprotnik, Sonja
Topics
Hypertension, Pulmonary |
Physiopathology |
Drug Therapy |
Endothelium, Vascular |
Pathology |
Epoprostenol |
Nitric Oxide |
Endothelins |
Thromboxanes |
Dušikov oksid |
Endotelij žilni |
Endotelini |
Epoprostenol |
Hipertenzija pljučna |
Tromboksani |
pljučna hipertenzija |
arterijska hipertenzija |
zdravljenje
source: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 72, št. 6, jun. 2003, str. 381-385)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Salobir, Barbara, 1966- | 12541 |
Šabovič, Mišo | 08094 |
Praprotnik, Sonja | 13602 |
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