Vpliv spremljajočih bolezni in škodljivih razvad na uspeh zdravljenja bolnikov z rakom grla = Impact of comorbidity and harmful habits on treatment success in patients with laryngeal cancer
Pukl, Peter, dr. med. ; Hočevar-Boltežar, Irena ; Šmid, Alojz, 1941-
Background Survival of the patients with head and neck cancer is affected by the tumor stage and also by comorbidity. The aim of the study was to evaluate the impact of comorbidity (respiratory, ...cardiovascular, gastrointestinal, neurological and systemic diseases) and harmful habits on treatment results oflaryngeal cancer. Methods Eighty-nine patients with squamous cell carcinoma of the larynx (92% men) who had been surgically treated at the University Department of Otorhinolaryngology and Cervicofacial Surgey in Ljubljana between January 1, 1996 and December 31, 1998 have been included into the retrospective study. Most of the patients were treated with radiotherapy or chemotherapy for the same cancer at the lnstitute of Oncology in Ljubljana. The medical data were obtained from medical hospital records, the data of Slovene Registry of Cancer and the Slovene Institute for Health Care. Results The mean age of the patients was 59.5 years. There were only 4% of non-smokersin the studied population. In 33% of patients excessive consumptionof alcohol was documented. In 84% of all patients at least osae comorbidity was detected. Fifty fourpercent of them had pulmonary, 39% cardiovascular, 26% systemic, 25 gastrointestinal, and 3% neurological diseases. Significantly shorter 5 year survival was found in patients with an advanced tumour (p = 0.002 chi2), neck metastases (p = 0.000 chi2), and advanced age (0.042 chi2). The results of the study presented a significant impact of alcohol consumption on survival of our patients (p = 0.014 chi2). The comorbidity was detected more often in patients with excessive alcohol consumption (p = 0.046 chi2) and in olclerpatients (0.018 chi2). The anaesthesiologist s assessment of the patientsć health status also influenced their 5 year survival (p = 0.014 (Fisher exact)). (Abstract truncated at 2000 characters)
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