Institute of Oncology, Lj. (OILJ)
-
Napovedni pomen urokinaznega aktivatorja plazminogena, njegovih inhibitorjev in receptorja pri raku dojke : [doktorsko delo]Borštnar, Simona, 1967-The prognosis of cancer is primarlly dependent on its potential to invade and metastasize. Urokinase-type plasminogen activator (uPA), its inhibitors (PAI-Zand PAI-2) and lts receptor (uPAR) all play ... a key role in tumor invasionand metastasis. The primary endpoint of our study was to evaluate the prognostic impact of PAI-1 and the three other components of the urokinase-type plasminogen ativator sysiem (uPA, PAI-Z and uPAR) as well as their combination in a group of 460 primary breast cancer patients. The secondary endpoint was to evaluate the prognostic impact of these factors in asubgroup of breast cancer patients This study included 460 patients with operable breast cancer, who are treated at the Institute of Oncology between 1997 and 1998. Cytosols and Triton X-ZOO extracts were prepared from the breast cancer tumors immediately after suegery. Content of uPA, PAI-Z and uPARwas measured in tumor extracis while aontent of PAI-2 was measured in tumor cytnsols, using ELISAs. Correlations belween invasive markers and other tumor characteristics were analyzed using Spearman rank correlation (rs) and Mann- Withney test. The optlmized cut-off of uPA, PAI-1, PAI-2 and uPAR was determined. Disease-free survival (DFS) according to all variables was calculated by Kaplan-Meier method, and the differences were assessed with the !og-rank test Univariate and multivariate analyses were performed by applying the Cox proportional hazards model. After a median follow-up of 33 months, 18.5% of the patients relapsed. We demonstrated that PAI-1, as wel! as PAI-2, provide independent prognostic information in breast cancer. Patients with either low values of PAI-1 or high values of PAI-2 were found to have better DFS (RR was 2.67 and 0.58, respectively). (Abstract truncated at 2000 characteristics).Type of material - dissertationPublication and manufacture - Ljubljana : [S. Borštnar], 2003Language - slovenianCOBISS.SI-ID - 2503700
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Call number – location, accession no. ... |
Copy status | Reservation |
---|---|---|
Knjižnica N DIS BORŠTNAR S Napovedni 0000000056 IN: 0012473 Knjižnica N DIS BORŠTNAR S Napovedni 56 IN: 0012473 |
available - outside loan, loan period: 7 days
|
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Borštnar, Simona, 1967- | 16303 |
Čufer, Tanja, 1955- | 12179 |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location: