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Intradermal DNA vaccination combined with dual CTLA-4 and PD-1 blockade provides robust tumor immunity in murine melanoma [Elektronski vir]Kos, Špela, farmacija ...We aimed to explore whether the combination of intradermal DNA vaccination, to boost immune response against melanoma antigens, and immune checkpoint blockade, to alleviate immunosuppression, ... improves antitumor effectiveness in a murine B16F10 melanoma tumor model. Compared to single treatments, a combination of intradermal DNA vaccination (ovalbumin or gp100 plasmid adjuvanted with IL12 plasmid) and immune checkpoint CTLA-4/PD-1 blockade resulted in a significant delay in tumor growth and prolonged survival of treated mice. Strong activation of the immune response induced by combined treatment resulted in a significant antigen-specific immune response, with elevated production of antigen-specific IgG antibodies and increased intratumoral CD8+ infiltration. These results indicate a potential application of the combined DNA vaccination and immune checkpoint blockade, specifically, to enhance the efficacy of DNA vaccines and to overcome the resistance to immune checkpoint inhibitors in certain cancer types.Source: PloS one [Elektronski vir]. - ISSN 1932-6203 (Vol. 14, no. 5, May 2019, str. [1-18])Type of material - e-articlePublish date - 2019Language - englishCOBISS.SI-ID - 3256187
Author
Kos, Špela, farmacija |
Lopes, Alessandra |
Préat, Véronique |
Čemažar, Maja |
Lampreht Tratar, Urša |
Učakar, Bernard |
Vanvarenberg, Kevin |
Serša, Gregor |
Vandermeulen, Gaëlle
Topics
melanom |
plazmidi |
DNK cepljenje |
eksperimentalna onkologija |
melanoma |
plasmids |
DNA vaccination |
experimental oncology
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Kos, Špela, farmacija | 36366 |
Lopes, Alessandra | |
Préat, Véronique | |
Čemažar, Maja | 14575 |
Lampreht Tratar, Urša | 36367 |
Učakar, Bernard | |
Vanvarenberg, Kevin | |
Serša, Gregor | 08800 |
Vandermeulen, Gaëlle |
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