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Epigenome-wide association study detects a novel loci associated with central obesity in healthy subjects [Elektronski vir]Xie, Ting ...Background and aims: Central obesity is a condition that poses a signifcant risk to global health and requires the employment of novel scientifc methods for exploration. The objective of this study ... is to use DNA methylation analysis to detect DNA methylation loci linked to obesity phenotypes, i.e. waist circumference and waist-to-hip ratio adjusted for BMI. Methods and results: Two-hundred and ten healthy European participants from the STANISLAS Family Study (SFS), comprising 73 nuclear families, were comprehensively assessed for methylation status using Illumina Infnium HumanMethylation450 BeadChip. An epigenome-wide association study was performed, which identifed a CpG site cg16170243 located on chromosome 18q21.2 signifcantly associated with waist circumference, after adjusting for BMI (β=2.32, SE=0.41, Padj=0.048). Cg16170243 corresponds to a 50 bp-length human methylation oligoprobe located within the AC090241.2 gene that overlaps ST8SIA5 gene. No signifcant association was observed with waistto-hip ratio adjusted for BMI (Padj>0.05). Conclusions: A novel association between DNA methylation and WC was identifed, which is demonstrating that epigenetic mechanisms may have a signifcant impact on waist circumference ratio in healthy individuals. Further studies are warranted to address the causal efects of this association.Source: BMC medical genomics [Elektronski vir]. - ISSN 1755-8794 (Vol. 14, no. 1, 2021, 8 str.)Type of material - e-articlePublish date - 2021Language - englishCOBISS.SI-ID - 104495875
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| Database name | Field | Year |
|---|
| Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
|---|---|
| Xie, Ting |  |
| Gorenjak, Vesna, 1991- | 40701 |
| Stathopoulou, Maria G | |
| Dadé, Sébastien | |
| Marouli, Eirini | |
| Masson, Christine | |
| Murray, Helena | |
| Lamont, John V. | |
| Fitzgerald, Peter | |
| Deloukas, Panos | |
| Visvikis-Siest, Sophie | |
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