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Vezava izbranih protimikrobnih učinkovin na hemoadsorbent Cytosorb in vitro = In vitro binding of selected antimicrobial agents to Cytosorb hemoadsorbent : enoviti magistrski študijski program FarmacijaCink, TejaSepsa je življenjsko ogrožajoča motnja v delovanju organov, ki nastane zaradi neustreznega odziva organizma na okužbo. V sistemski krvni obtok se sproščajo povečane količine mediatorjev vnetja. To ... vodi do sistemskih sprememb organizma, kar bistveno poveča smrtnost. Poleg protimikrobnega zdravljenja se v zadnjem času pri zdravljenju sepse uporablja hemoadsorbent CytoSorb, ki odstranjuje mediatorje vnetja. Raziskovalci so in vitro ter na živalskih modelih dokazali, da Cytosorb lahko veže tudi nekatere protimikrobne učinkovine. V magistrski nalogi smo želeli ugotovili v kakšni meri se na CytoSorb in vitro adsorbirajo antibiotiki vankomicin, piperacilin in meropenem. In vitro poskus je bil zasnovan v stekleni čaši, v katerih smo kri segrevali na 37 °C in med mešanjem spremljali vezavo izbranih protimikrobnih učinkovin na hemoadsorbent CytoSorb. Pri tem smo simulirali kri septičnega bolnika tako, da smo v goveji krvi s citratnim antikoagulantom uravnali koncentracijo albumina na 20 g/l in delež hematokrita na 30 %. Uporabili smo enostavni metodi in sicer smo spektrofotometrično določali koncentracijo albuminov, medtem ko smo hematokrit določili v kapilarah po centrifugiranju. Z ustreznim odvzemom plazme in dodatkom fosfatnega pufra s pH 7,4 smo prilagodili govejo kri. Med poskusom smo spremljali tudi delež hemolize. Za njen izračun smo potrebovali vrednosti hemoglobina v polni krvi in plazmi, katerega smo določali spektrofotometrično. In vitro poskus smo izvedli v treh delih. V prvem delu smo z merjenjem hemolize določili ustreznost pogojev poskusa (190 obrt/min, 37 °C). V drugem delu smo dokazali, da terapevtske koncentracije izbranih antibiotikov ne vplivajo na hemolizo prilagojene krvi ter določili vpliv pogojev poskusa na koncentracijo antibiotika. V zadnjem sklopu poskusov smo v prilagojeni krvi določili vezavo antibiotikov na hemoadsorbent CytoSorb. Vezavo antibiotikov na CytoSorb smo spremljali 6 ur z 0,1 g in 1 g CytoSorba v 100 ml goveje krvi. Rezultati naloge nakazujejo zelo verjetno vezavo izbranih protimikrobnih učinkovin na hemoadsorbent CytoSorb. Pri tem smo ugotovili, da različna masa CytoSorba vpliva na delež adsorpcije antibiotikov na hemoadsorbent. Razvit in vitro model je dobro orodje za proučevanje vezave učinkovin na hemoadsorbent in bo zato uporaben v nadaljnjih raziskavah.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [T. CInk], 2022Language - slovenianCOBISS.SI-ID - 124111363
Author
Cink, Teja
Other authors
Vovk, Tomaž, 1972- |
Kenda, Sara
Topics
Sepsa |
Antibiotiki |
Dojenje |
CytoSorb |
hemoliza |
hemoadsorpcija
Library | Call number – location, accession no. ... | Copy status |
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Faculty of Pharmacy, Lj. | Knjižnica emšf 615.3 CINK TEJA Vezava 1159 IN: 0017420 |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Cink, Teja | |
Vovk, Tomaž, 1972- | 18155 |
Kenda, Sara |
Source: Personal bibliographies
and: SICRIS
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