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Platelet gel stimulates proliferation of human dermal fibroblasts in vitroKrašna, Metka ...Background: Platelet gel is a source of many soluble proteins that can modulate tissue regeneration. Dermal fibroblasts play an important role in tissue remodeling and wound healing. Objective: The ... study was performed to investigate the influence of platelet gel and its active ingredients on the proliferation of human dermal fibroblasts in vitro. Methods: A fibroblast culture was established from a normal human skin biopsy. Platelet gel was prepared from platelet-rich plasma (PRP) following the addition of calcified thrombin solution. cell proliferation was measured by MTT assay. Results: We showed that platelet gel, PRP, and thrombin stimulate the proliferation of dermal fibroblasts, and that stimulation by PRP is dose dependent. Conclusion:Platelet gel can be used to treat chronic skin defects.Source: Acta dermatovenerologica Alpina, Panonica et Adriatica. - ISSN 1318-4458 (Letn. 16, št. 3, September 2007, str. 105-110)Type of material - article, component partPublish date - 2007Language - englishCOBISS.SI-ID - 23488729
Author
Krašna, Metka |
Domanovič, Dragoslav |
Herman, Ana, farmacevtka |
Švajger, Urban |
Jeras, Matjaž
Topics
Fibroblasts |
Cells, Cultured |
Blood Platelets |
Cell Division |
Celična delitev |
Celične kulture |
Fibroblasti |
Trombociti
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source: Acta dermatovenerologica Alpina, Panonica et Adriatica. - ISSN 1318-4458 (Letn. 16, št. 3, September 2007, str. 105-110)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Krašna, Metka | 21227 |
Domanovič, Dragoslav | 15980 |
Herman, Ana, farmacevtka | 31225 |
Švajger, Urban | 26198 |
Jeras, Matjaž | 01302 |
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