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Razvoj in vrednotenje redisperzibilnih posušenih emulzij s simvastatinom, izdelanih z metodo oblaganja pelet = Development and evaluation of redispersible dry emulsion systems containing simvastatin, produced by using fluid bed coating : enoviti magistrski študijski program FarmacijaHauko, SašaEmulzije so učinkoviti pristop povečanja biološke uporabnosti slabo vodotopnih učinkovin, vendar se pogosto srečujemo s pojavom flotacije, koalescence in Ostwaldovim zorenjem ter fazno inverzijo, kar ... povzroča težave s stabilnostjo teh dvofaznih sistemov. Ena od strategij za izboljšanje lastnosti klasičnih emulzij je njihovo preoblikovanje v posušene emulzije. V sklopu magistrske naloge smo z metodo zvrtinčenih plasti obložili pelete z emulzijo O/V, v katero je bila v oljno fazo vgrajena modelna učinkovina simvastatin, v vodni fazi pa raztopljen hidrofilni matriks ogrodja emulzije. Cilj magistrske naloge je bil razviti in izdelati s posušeno emulzijo obložene pelete, ki bodo izkazovale ustrezno fizikalno ter kemijsko stabilnost ter kot take v ločeni študiji potencialno izkazovale izboljšane biofarmacevtske lastnosti v primerjavi s klasično oblikovanim izdelkom na trgu. S preliminarnimi testi smo določali sestavo emulzije in določali kar najbolj optimalne procesne parametre. Za dosego optimizacije sestav formulacij emulzije smo ob izbrani procesni komori in vrednostih procesnih spremenljivk uporabili dve kritični lastnosti izdelka - odziva (sposobnost rekonstitucije emulzije in parameter enomesečne stabilnosti učinkovine) in ju po konceptu načrtovanja eksperimentov popisali z matematičnima modeloma. Pelete obložene s posušeno emulzijo so izkazovale ustrezno majhno širino porazdelitve velikosti, okroglo obliko in vsebnost vode manjšo od 1,5 %. Optimizirane formulacije so po rekonstituiranju v vodnem mediju izkazovale ozko porazdelitev velikosti kapljic olja z učinkovino, ustrezno stabilnost, učinkovito vgradnjo zdravilne učinkovine in izboljšani profil sproščanja v primerjavi z ne-lipidno formulacijo tablet, ki je trenutno dostopna na trgu in v primerjavi s čisto učinkovino.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [S. Hauko], 2020Language - slovenianCOBISS.SI-ID - 27656707
Author
Hauko, Saša
Other authors
Dreu, Rok |
Pohlen, Mitja
Topics
Farmacevtska tehnologija |
Farmacevtske oblike |
lipidni sistemi |
emulzije |
posušena emulzija |
tehnologija zvrtinčenih plasti |
simvastatin |
intestinalni limfni transport |
pelete
Library | Call number – location, accession no. ... | Copy status |
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Faculty of Pharmacy, Lj. | Knjižnica emšf 547 HAUKO SAŠA Razvoj 880 IN: 0016679 |
available - reading room |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Hauko, Saša | |
Dreu, Rok | 21455 |
Pohlen, Mitja | 50269 |
Source: Personal bibliographies
and: SICRIS
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