Bloodcompatibility assessment of modified poly(ethylene)terephthalate surfaces [Elektronski vir]
Stana, Jan ...
The main causes of death in the modern world are cardiovascular diseases, mainly atherosclerosis. The treatment of choice for these diseases is often implantation of vascular grafts, heart valves, ...stents, etc. The developments of hemocompatible biomaterials therefore represent a very important challenge in Material Science. However, owing to the complex influences of several experimental conditions on the in-vitro alteration of blood, there is still a lack of viable in-vitro tests and methods for biomaterials bloodcompatibility evaluation. The aim of this research was to introduce a method for analysing the hemocompatibility of different chemically-modified poly(ethylene terephthalate) (PET) surfaces. PET, as well as different polysaccharides and their derivatives, were chosen for this study due to their promising biocompatible properties and numerous possibilities for use in biomedical applications. The haemoglobin-free method was used in order to determine the hemocompatibility of modified PET surfaces. The method was so far used for the determination of blood-contacting properties of chemically different materials [1, 2]. To achieve the goals of this research the method had to be optimised regarding shaking rate, buffer addition, and blood temperature in order to decrease measuring deviations, and in this way to increase the method's sensitivity in differentiation of chemically alike surfaces. Five differently-modified PET surfaces were analysed: chemically pretreated PET and PET treated with chitosan, fucoidan, chitosan suphate, and heparin. Glass surface was used as a standard thrombogenic material. The optimisation process was successful. The results proved that the lowering of the shaking rate, buffer addition, and blood cooling prior to measurement significantly decreased the standard deviation of the results. Applying the optimised method, the results showed that PET surfaces treated with alternative sulphated polysaccharides regarding anticoagulant properties approached the properties of PET surface treated with heparin.
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