E-resources
Peer reviewed
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Wang, Jia-Yin; Li, Guigen; Hao, Wen-Juan; Jiang, Bo
Organic letters, 05/2021, Volume: 23, Issue: 10Journal Article
A new asymmetric catalytic conjugate reduction of yne-allenones to synthesize enantioenriched cyclobuta naphthalen-4(2 )-ones has been established that uses copper-bisphosphine complexes as catalysts and gives excellent regio- and enantioselectivities (≥99% ee) in most cases. This protocol tolerates a broad scope of substrates, exhibits high compatibility with various substituents, and gives excellent stereoselectivity, providing a catalytic and efficient entry to fabrication of synthetically important chiral 6-6-4 tricarbocyclic scaffolds.
